Vitamin D Plays Key Role In Strong Immune Systems
Various studies, a association between severe vitamin D deficiency and bad COVID-19 outcomes. Vitamin D plays a crucial role in immune function and inflammation.
Recent data suggest a protective role of vitamin D against bad outcomes.
Nutraceutical approach Promote the immune response and reduce the inflammatory response.
Anti-inflammatory, antioxidant, and immunomodulatory properties of vitamin D Immune optimisation and immune boosting.
Vitamin D maintains pulmonary barrier function Determines the production of antimicrobial peptides Enhances neutrophil activity Shifts the adaptive immune response to a more T helper cell-2 type
Anti-inflammatory effects of vitamin D Reduces the production of pro-inflammatory cytokines, such as IL-6, IL-8, IL-9, IL-12, TNF alfa, IFN gamma Increases production of anti-inflammatory cytokines, such as IL-4, IL-5, IL-10 Patients with a low baseline vitamin D, more benefit Reduce risk of asthma exacerbations
Prevents acute respiratory infections, and reducing their complications COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials https://www.ncbi.nlm.nih.gov/pmc/arti…
The rates of RT-CR positivity were significantly decreased in the intervention group as compared to the non-vitamin D groups (RR = 0.46) Conclusively, COVID-19 patients supplemented with vitamin D, fewer rates of ICU admission, mortality events, and RT-PCR positivity. Meta-analysis and trial sequential analysis (TSA) Better explain the strength of association Protective role of vitamin D supplementation, and risk of mortality / admission to intensive care units
We searched four databases on 20 September 2022. Screened the randomized clinical trials (RCTs) Assessed the risk of bias (how to adjust thresholds for significance in randomised clinical trials when the required sample size has not been reached)
The pre-specified outcomes of interest Mortality and ICU admission 78 bibliographic citations Five RCTs were suitable for our analysis Results Vitamin D administration results in a decreased risk of death, 0.49 Vitamin D administration results in a decreased risk of ICU admission, 0.28 Protective role of vitamin D and ICU admission
The TSA of the protective role of vitamin D and ICU admission showed that, since the pooling of the studies reached a definite sample size, the positive association is conclusive. The studies Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial https://www.mdpi.com/2072-6643/13/7/2170
(Saudi) Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study https://www.ncbi.nlm.nih.gov/pmc/arti…
(Spain) Changes in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D https://www.ncbi.nlm.nih.gov/pmc/arti…
(Spain) Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 https://www.ncbi.nlm.nih.gov/pmc/arti…
(Brazil) Calcifediol treatment and COVID-19-related outcomes https://www.ncbi.nlm.nih.gov/pmc/arti…
(Spain) Medicines & Healthcare products Regulatory Agency https://www.bmj.com/content/377/bmj.o… 86% industry funded
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Alan
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Did anybody bother to read any of the references before publishing thia?
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Andy Rowlands
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Is there a problem with the references?
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Jerry Krause
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Hi Andy<
I do not know what this means; but when I click on a link to a reference I am asked if I want to leave “you tube”. This is not my usual experience and maybe it is what Alan questions.
Have a good day, Jerry
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Typhus
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Isn’t there recent research showing that too much Vit D uptake enables calcium leaching from the bones into the blood?
Thus leading to other issues…lining blood vessels with calcium…heart valves with calcium…kidney stones.
Were you aware that the aorta heart valve is particularly susceptible to this calcium buildup..leading to replacement…which might last 12 years…
This last got my attention a year ago…that led to further research.
Maybe a key is to not take Vit D in a vacuum.
Vit K2 may help counteract this by fixing calcium in the bones…while adding Magnesium seems to help in some way.
This is another complex process that seems largely unexplored.
Calcium supplements might also be a problem by themselves… leading to the same effect of too much of it in blood solution…leading to the aforementioned issues.
A continuing question….can calcium build up in blood vessels & heart valves be dissolved??? There are inconclusive experiments on it.
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