US quietly terminates controversial wildlife virus hunting program amid safety fears
My dire warnings about the plan to aggressively hunt for “potential pandemic pathogens” has been heeded–but by only one US agency
I warned my readers about this reckless program here and the USAID described it here:
Searching for future pandemic viruses is exactly what the proposed WHO Treaty (in its most recent Bureau Text version) demands of its member nations, and what I warned about in writings and on the Highwire last week.
Other similar programs, however, continue. They all need to be shut down, with effective oversight guaranteeing they don’t continue in the shadows.
As Del pointed out, the WHO proposal calls for “Open-Source” biological warfare agents. To be “shared globally.”
Article 12 of the treaty has 2 options— but both require nations to share the deadly potential pandemic pathogens.
From Option A on page 19:
1. The Parties agree that pandemic prevention, preparedness, response and health system recovery requires the rapid, systematic, and timely sharing of biological materials with epidemic and pandemic potential, as well as [genetic sequence data and relevant information]/[digital sequence information] (WHO CA+ biological material).
From Option B, right there on page 20 of the draft pandemic treaty. “Shall” in legal language means must. Everyone needs to look at this treaty:
5. Biological materials-sharing:
(a) Each Party, through its relevant public health authorities and authorized laboratories, shall, in a rapid, systematic and timely manner:
(i) provide pathogens with pandemic potential from early infections due to pathogens with pandemic potential or subsequent variants to a laboratory recognized or designated as part of an established WHO coordinated laboratory network; and
(ii) upload the genomic sequence of such pathogens with pandemic potential to one or more publicly accessible database(s) of its choice.
Below is the British Medical Journal article regarding the cancellation of the USAID program to hunt new pandemic pathogens.
BMJ 2023; 382 doi: https://doi.org/10.1136/bmj.p2002 (Published 07 September 2023) Cite this as: BMJ 2023;382:p2002
By David Willman. The BMJ’s editor in chief, Kamran Abbasi, explains more about this investigation
Two years after launching what officials hailed as a five year flagship project for hunting viruses among wildlife to prevent human pandemics, the US Agency for International Development is shuttering the enterprise. David Willman reports
A flagship project for the controversial practice of hunting viruses among wildlife in South East Asia, Africa, and Latin America to prevent human outbreaks and pandemics is being quietly dropped by the United States Agency for International Development (USAID) after private and bipartisan criticism over the safety of such research, The BMJ has found.
For more than a decade the US government has been funding international projects engaged in identifying exotic wildlife viruses that might someday infect humans. Although critics have raised concerns over the potentially catastrophic risks of such virus hunting activities,1 hundreds of millions of dollars in unabated funding have symbolised a commitment to the effort.
The shuttering of the project, as described in a new congressional budget document and during interviews with scientists and federal policy makers, marks an abrupt retreat by the US government from wildlife virus hunting, an activity that has also been funded by the Department of Defense and the National Institutes of Health. The turnabout follows early warnings raised by sceptics—including officials in the Biden White House—that the $125m (£99m; €115m) “DEEP VZN” programme could inadvertently ignite a pandemic. The misgivings continue to resonate, as the cause of the SARS-CoV-2 pandemic, the world’s deadliest such event in a century, remains unproved.
When USAID, an arm of the US State Department, launched DEEP VZN (pronounced “deep vision”) in October 2021, the agency promoted it as “a critical next step . . . to understand and address the risks posed by zoonotic diseases that can be transmitted from animals to humans.”2 Short for “Discovery & Exploration of Emerging Pathogens—Viral Zoonoses,” DEEP VZN succeeded an earlier USAID programme called PREDICT and aimed to find previously unknown pathogens from three viral families: coronaviruses; filoviruses, such as Ebola; and paramyxoviruses, including Nipah virus. The aim was to help the world “be better prepared to detect, prevent and respond to future biological threats.”2
Officials at Washington State University, hired by USAID to help administer DEEP VZN, said in a submission to the agency that the university’s goal was to collect around 480 000 samples from wildlife, seeking out “previously unknown” viruses to “identify a subset that pose a significant pandemic threat.” The university said that the project aimed to “detect and characterize” as many as 12 000 novel viruses over the programme’s five years.3
Beginning in July of this year, however, officials at USAID quietly informed aides to Democratic and Republican members of two Senate committees with jurisdiction over DEEP VZN that it was being shut down. Apart from the Biden White House officials, several Republican senators had questioned the prudence of DEEP VZN, according to Senate letters and the interviews conducted for this article.
The previously unpublicised decision by USAID to terminate DEEP VZN comes amid heightened concerns over the many risks of working with exotic viruses—including unresolved questions about whether a research mishap or a naturally occurring spillover of virus from an animal species to humans caused the SARS-CoV-2 pandemic.4 In China, where a separate effort to catalogue viruses has been under way for years, scientists have described being bitten or scratched by bats or having bat urine or blood splashed into their eyes and faces.567
The closure of DEEP VZN was privately relayed to the Senate aides by the office of Atul Gawande, USAID’s assistant administrator for global health, said officials familiar with the matter. Gawande, an appointee of President Biden, was a general and endocrine surgeon and bestselling author before joining the administration in January 2022.
Weighing risks against potential benefits
The demise of DEEP VZN, despite its backing from proponents at USAID and the project’s grantees, validates the concerns of sceptics, including the handful of Biden White House officials who challenged the project.
In December 2021 two senior White House officials specialising in biosecurity and biosafety—Jason Matheny, deputy assistant to Biden for technology and national security, and Daniel Gastfriend, the National Security Council’s director for biodefence and pandemic preparedness—first privately shared their views with USAID’s administrator, Samantha Power, and advised her to shut down DEEP VZN. Those familiar with the matter said that another White House official, T Gregory McKelvey Jr, a physician and the assistant director for biosecurity with the Office of Science and Technology Policy, also privately raised concerns with USAID staff.
The White House officials’ remarks to Power in late 2021 and other details surrounding DEEP VZN were first reported by the Washington Post on 10 April this year.5 Power, a presidential appointee and Harvard trained lawyer, eventually told Matheny and Gastfriend that she would initiate a review of the project to ensure that DEEP VZN could be conducted in a way that adequately managed the risks, according to those with knowledge of the conversation.
In March and November 2022 USAID directed its grantees to avoid collecting samples of viruses until safety protocols were reviewed anew. However, federal records state that through spring of this year USAID continued to fund the research while its project administrators lined up additional laboratories, technicians, and other support staff necessary to manage the expected volume of genetic samples.
The ultimate decision to terminate DEEP VZN reflected the Biden administration’s commitment to weigh more rigorously the risks and the potential benefits of research projects, according to interviews with present and former White House officials. They pointed to a policy recommendation issued in March by the National Science Advisory Board for Biosecurity, calling for such work to be approved only if “there are no feasible alternative methods of obtaining the relevant benefits from proposed research that pose less risk,” and after “unnecessary risks have been eliminated and the remaining risks are justified by the potential benefits.”8
In response to written questions, a USAID spokesperson confirmed on Wednesday 6 September that the agency has decided to close down DEEP VZN.
“USAID has determined that investments that focus on the search for and characterization of unknown viruses prior to spillover into humans are not an Agency global health security priority at this time. As a result, we will cease funding projects with this specific objective,” said the agency’s prepared statement.
Asked to what extent USAID leadership’s decision to shutter DEEP VZN hinged on concerns over its risks, the agency said that the decision reflected “the relative risks and impact of our programming.”
Instead of collecting viruses circulating exclusively among wildlife, USAID said that “the change in Agency priorities” would emphasise actions aimed at improving global “laboratory capacity, disease surveillance, human resources, biosafety and biosecurity, and risk communication and community engagement.” The agency said that it had informed Washington State University and other stakeholders beginning in July of USAID’s decision “to end the DEEP VZN” project.
Power did not respond to a request for her rationale with DEEP VZN. Gawande was described by an aide, Enam Hussain, as unavailable to speak on the record.
Matheny, who left the White House in mid-2022 to become president and chief executive officer of the RAND Corporation, told The BMJ he believed that USAID’s about-face with DEEP VZN stemmed from the newfound media scrutiny and serious safety considerations.
“It seems likely that the agency assessed that the risks exceeded the benefits of the programme,” said Matheny, noting that jettisoning DEEP VZN cut against USAID’s backing of such research, which has spanned three presidential administrations and surpassed $300m in funding. “USAID has consistently seen this viral discovery work as ‘part of our mission.’”
Although the agency has backed wildlife virus hunting since 2009, its historical and chief focus has been to mitigate suffering from disease, famine, and other natural disasters in resource challenged regions.
DEEP VZN’s grantees have included Washington State University, the University of Washington, Washington University in St Louis, PATH (formerly the Program for Appropriate Technology in Health), and FHI 360, a contractor based in Durham, North Carolina.9 On 1 October 2021 USAID awarded Washington State University $124.7m to provide overall support for DEEP VZN.
The University of Washington was retained as a sub-grantee and was intended to provide expertise from five of its labs to build “capacity in other countries to be able to find new viruses and characterize them,” according to a university issued news item.10 In July 2022 USAID awarded an additional $1.1m to FHI 360, whose representative was installed as a project leader to help provide “expert technical guidance,” programme documents show.
Matheny and Gastfriend had first contacted Power at USAID on learning that Kevin Esvelt, a prominent Massachusetts Institute of Technology biotechnologist, was about to warn in public testimony to the House Foreign Affairs Committee on 8 December 2021 that pursuing novel, animal transmitted viruses could be exploited by terrorists and lead to a pandemic.
That same day, coincidentally, the director of the White House Office of Science and Technology Policy, Eric S Lander, publicly discounted the benefits of wildlife virus hunting—a position at stark odds with the long running advocacy for such work from USAID, the Department of Defense, and leaders of the National Institutes of Health. Appearing before the privately funded Bipartisan Commission on Biodefense, Lander, appointed by Biden, was asked by the former Senate majority leader Tom Daschle, a Democrat, whether pandemics could be predicted or prevented.
“OK, I may get myself in trouble,” replied Lander, an expert on sequencing and interpreting the human genome. “I’m just not an optimist on the question, because nature is vast. There are viruses that can jump species—and we do not know how to take a virus from the animal kingdom and recognise when it is ready to jump species.”11
Research with a history of controversy
Well before the SARS-CoV-2 pandemic, other sceptics of wildlife virus hunting had dismissed such projects as unlikely to deliver lifesaving medicines or prevent pandemics. Writing for the journal Nature in June 2018, the biologists Edward Holmes, Andrew Rambaut, and Kristian Andersen said, “Making promises about disease prevention and control that cannot be kept will only further undermine trust.” They described assumptions that such virus hunting projects could succeed as “misguided” and “arrogant.”12
In the wake of the SARS-CoV-2 pandemic others have raised additional concerns, saying that the risks of collecting animal-to-animal transmitted viruses should not be dismissed lightly. Such research typically entails collecting biological specimens—such as excrement, blood, or saliva from bats dwelling in caves or tree groves—followed by shipments of the samples to one or more labs for analysis. A mishap at any stage of the work would, some experts warn,4 invite the risk of an outbreak or a pandemic.
This is taken from a long document. Read the rest here substack.com
Header image: bucketteer / amazonaws2
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Wildlife viruses do not exist, otherwise humanity would have been taken out thousands of years ago.
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