Scientists Show How Risky COVID Vax Proteins Damage Healthy Cells

Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease.

LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself.

The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19’s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies.

A lot of people think of it as a respiratory disease, but it’s really a vascular disease,” says Assistant Research Professor Uri Manor, who is co-senior author of the study. “That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.

Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others.

While the findings themselves aren’t entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. There’s been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented.

In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model—proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.

The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.

Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own.

If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,” Manor explains. “Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.”

The researchers next hope to take a closer look at the mechanism by which the disrupted ACE2 protein damages mitochondria and causes them to change shape.

Other authors on the study are Yuyang Lei and Zu-Yi Yuan of Jiaotong University in Xi’an, China; Cara R. Schiavon, Leonardo Andrade, and Gerald S. Shadel of Salk; Ming He, Hui Shen, Yichi Zhang, Yoshitake Cho, Mark Hepokoski, Jason X.-J. Yuan, Atul Malhotra, Jin Zhang of the University of California San Diego; Lili Chen, Qian Yin, Ting Lei, Hongliang Wang and Shengpeng Wang of Xi’an Jiatong University Health Science Center in Xi’an, China.

The research was supported by the National Institutes of Health, the National Natural Science Foundation of China, the Shaanxi Natural Science Fund, the National Key Research and Development Program, the First Affiliated Hospital of Xi’an Jiaotong University; and Xi’an Jiaotong University.

See more here: salk.edu

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Comments (9)

  • Avatar

    Chris

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    All that this has done is proven that the vaccines can cause another harm. There is no indication here that sars2 is real. If the author wants this paper to be better they need to drop the discussion about sars2 because after a year and they still haven’t found it means that this is a hoax. But it does show that the protein from the vaccine can cause a particular harm. Add this to the other list of damage caused by this vax.

    Reply

  • Avatar

    Tom

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    …”In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus”…so why not use the actual virus to be more conclusive with these kinds of studies? Could it be that the real SARS CoV-2 phantom particles do not exist? While I can appreciate these types of studies, they may still be highly questionable.

    This is very similar to the mRNA potions; or, gene re-producing synthetic therapies that used an algorithm to create a particle that estimates what the actual virus might be and then tries to create a spike protein that will battle the presumed, concocted virus. What happens if the simulated particles from which the spike proteins are thought to be close relatives are not close enough?

    So where is the actual, factual virus? This is what many previous vaccines (totally unlike the new mRNA types) have been formulated with…a sprig of the real thing. So far, no one in the world has been able to produce an atom’s worth of SARS CoV-2. With virtually thousands of labs and medical facilities around the world working on Covid, where is the real deal? After 15 months we can’t produce anything? This is the kind of science that makes anyone question this entire fake pandemic. You scientists can’t prove a dang thing!

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    Mora

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    I really don’t see how this story bears out your headline “Scientists Show How Risky COVID Vax Proteins Damage Healthy Cells”. The article is about VIRUS proteins, not vax proteins. Your sentence “Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself” states that the vaccine proteins are safe. So what’s with your headline? Do you have some info that the vaccine proteins are actually NOT safe?

    Reply

    • Avatar

      Herb Rose

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      Hi Mora,
      If the spike protein they inject into you, or have your cells produce, was different than the one causing the disease the “vaccines” would not produce an immune response to the contagion. They put that nonsense in there to go along with the narrative and not cause the people who took the shot to realize that they’ve been poisoned.
      Herb

      Reply

      • Avatar

        Mark Tapley

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        Greetings Herb:
        Not seen any thing from you for a while. I thought maybe you had wondered off into the wrong section of Philadelphia and got hit with some of that ethnic diversity that is enriching the country.

        We know that the fake virus has never been purified isolated nor identified. Viruses have not even been shown to exist in spite of the large monetary reward offered by micro biologist Stephan Lanka who says they are just exosomes (cellular debris). The “spike protein” (only an artist depiction) is probably another subterfuge to disguise the usual injection of a chemotherapy protein blood toxin into the system. Obviously when there is no sample to begin with, there can be no protein to generate immunity. I also believe the shedding is another myth but that is not definite yet.

        Reply

        • Avatar

          Hrrb Rose

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          Hi Mark,
          When I was youngly friends and I all got the measles, mumps, chickenpox, and other diseases at about the same time despite differences in genetics, diet, and environment. This experience causes me to believe that there is some contagious entity that is transmitting certain diseases. Whether this is what is identified as a virus, prion, or some other unidentified entity is certainly debatable but for me the ability of external factors to transmit diseases is established. That doesn’t mean I’m not wrong, just that the evidence I’ve encountered needs to be shown to be wrong.
          Herb

          Reply

          • Avatar

            Carbon Bigfoot

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            Herb: Here is your culprit:
            The health effects of 5G will include skin carcinomas, optical deterioration and sterility, and when combined with 2,3,4G and Dirty Electricity will significantly increase the 36 diseases of the Digital Age. In a process which is triggered by microwave radiation, i.e., EMI/RF/EMF, and millimeter waves, will initiate calcium loading through VGCCs ( voltage-gated calcium channels ) creating Oxidative Stress, DNA damage by Peroxynitrite, the compound that is consistent with all 36 diseases of the Digital Age. Richard Lear, Brown University, an Engineer (of course) consolidated over 5000 studies linking Peroxynitrite as the cause. One more to add to the list.

        • Avatar

          Herb Rose

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          Hi again Mark,
          About shedding. Are you aware that when young women live together, as in a dormitory, their menstrual cycles tend to synchronize?
          Herb

          Reply

  • Avatar

    Mark Tapley

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    Hi Herb:
    The questions of shedding and transmission are basic to the issue of pathogens. It is normal to assume that people in the same area can spread pathogens to others. That is what has always been taught. However when we go back to the gold standard for this germ theory model, the Fauci of his day, Louis Pasteur, we see forty years of lies, deception and fraud.

    In his microscope, Pasteur could see in the tissue samples the presence of bacteria and so he assumed they were causing the illnesses, while others such as Beauchamp said the bacteria were just the clean up crew (causing inflammation, fever). Pasteur demonstrated repeatedly over many years that the pathogens were causing the disease. Only on his death bed did he recant and say “the germ is nothing, the terrain (condition of the animal) is everything.” He even left a diary that was never supposed to be published in which he categorized his experiments. Not once was he ever able to transmit a disease from one host to another unless he spiked the solution with a toxin, usually mercury or arsenic.

    During the 1918 “pandemic” caused by the Rockefeller blood toxins and aspirin along with every other death thrown in the bucket as well (just as now) the Boston study conducted extensive trials with volunteers to transmit or shed the alleged pathogen using every conceivable method to no avail.

    In the German supreme court, micro biologist Stephan Lanka using the example of the hypothetical measles virus has proven under scientific inquiry that the virus does not exist. There remains lots of money on the table for anyone who can prove measles existence to the court. There have been many attempts over the years to demonstrate pathogen transmission. All have been a failure. Dr. Tom Cowan says that measles is some kind of maturation phase that people go through. There are perhaps some type of signals that the body gives off with it as in the menstrual cycle. The question remains as to wether something can be transmitted or shed as a result of the chemotherapy injection. We hope to get more data on this soon.
    best regards,
    Mark

    Reply

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