Review of the Efficacy of Ivermectin To Treat COVID-19

After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within clinical trials.

Areas of Uncertainty:

The majority of trialed agents have failed to provide reproducible, definitive proof of efficacy in reducing the mortality of COVID-19 with the exception of corticosteroids in moderate to severe disease. Recently, evidence has emerged that the oral antiparasitic agent ivermectin exhibits numerous antiviral and anti-inflammatory mechanisms with trial results reporting significant outcome benefits.

Given some have not passed peer review, several expert groups including Unitaid/World Health Organization have undertaken a systematic global effort to contact all active trial investigators to rapidly gather the data needed to grade and perform meta-analyses.

Data Sources:

Data were sourced from published peer-reviewed studies, manuscripts posted to preprint servers, expert meta-analyses, and numerous epidemiological analyses of regions with ivermectin distribution campaigns.

Therapeutic Advances:

A large majority of randomized and observational controlled trials of ivermectin are reporting repeated, large magnitude improvements in clinical outcomes. Numerous prophylaxis trials demonstrate that regular ivermectin use leads to large reductions in transmission. Multiple, large “natural experiments” occurred in regions that initiated “ivermectin distribution” campaigns followed by tight, reproducible, temporally associated decreases in case counts and case fatality rates compared with nearby regions without such campaigns.

Conclusions:

Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin.

Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified.

INTRODUCTION

In early 2020, on the onset of the spreading pandemic, many providers and institutions began to continuously review the rapidly emerging basic science, translational, and clinical data to identify potentially effective treatment options for COVID-19. Although there is now a small and increasing number of therapeutics showing some efficacy in important clinical outcomes, chief of which are corticosteroids in moderate to severe illness, the world continues to suffer from a worsening crisis with the potential of again overwhelming hospitals and intensive care units (ICU).

As of February 21, 2020, the number of deaths attributed to COVID-19 in the United States reached 510,248 with more than 9.3 million active cases, the highest number to date. In addition, multiple European countries have imposed new rounds of restrictions and lockdowns.

Further compounding these alarming developments was a wave of recently published results from therapeutic randomized controlled trials conducted on medicines believed effective for COVID-19 that found a lack of impact on mortality in hospitalized patients with the use of remdesivir, hydroxychloroquine, lopinavir/ritonavir, interferon, convalescent plasma, and monoclonal antibody therapy.14

One year into the pandemic, the only therapy considered “proven” as a life-saving treatment in COVID-19 is the use of corticosteroids in patients with moderate to severe illness.5,6 Similarly, most concerning is the fact that no agent has yet proven effective in outpatients to prevent disease progression to prevent hospitalization.

More recently, trial results of ivermectin, a widely used antiparasitic medicine with known antiviral and anti-inflammatory properties, have been showing benefits in multiple important clinical and virologic outcomes, including mortality. Although growing numbers of the studies supporting this conclusion have passed through peer review, approximately half of the remaining trials data are from manuscripts uploaded to medical preprint servers, a now standard practice for both rapid dissemination and adoption of new therapeutics throughout the pandemic.

Following is a comprehensive review of the available efficacy data as of December 12, 2020, taken from in vitro, animal, clinical, and real-world studies all showing the above impacts of ivermectin in COVID-19.

History of ivermectin

In 1975, Professor Satoshi Omura at the Kitsato institute in Japan isolated an unusual Streptomyces bacterium from the soil near a golf course along the southeast coast of Honshu, Japan. Omura, along with William Campbell, found that the bacterial culture could cure mice infected with the roundworm Heligmosomoides polygyrus. Campbell isolated the active compounds from the bacterial culture, naming them “avermectins” and the bacterium S. avermitilis for the compounds’ ability to clear mice of worms.7

Despite decades of searching around the world, the Japanese microorganism remains the only source of avermectin ever found. Ivermectin, a derivative of avermectin, then proved revolutionary. Originally introduced as a veterinary drug, it soon made historic impacts in human health, improving the nutrition, general health, and well-being of billions of people worldwide ever since it was first used to treat onchocerciasis (river blindness) in humans in 1988.

It proved ideal in many ways, given that it was highly effective, broad-spectrum, safe, well tolerated, and could be easily administered.7 Although it was used to treat a variety of internal nematode infections, it was most known as the essential mainstay of 2 global disease elimination campaigns that has nearly eliminated the world of two of its most disfiguring and devastating diseases.

The unprecedented partnership between Merck & Co. Inc, and the Kitasato Institute combined with the aid of international health care organizations has been recognized by many experts as one of the greatest medical accomplishments of the 20th century. One example was the decision by Merck & Co to donate ivermectin doses to support the Mectizan Donation Program that then provided more than 570 million treatments in its first 20 years alone.8

Ivermectin’s impacts in controlling onchocerciasis and lymphatic filariasis, diseases which blighted the lives of billions of the poor and disadvantaged throughout the tropics, is why its discoverers were awarded the Nobel Prize in Medicine in 2015 and the reason for its inclusion on the World Health Organization’s (WHO) “List of Essential Medicines.” Furthermore, it has also been used to successfully overcome several other human diseases and new uses for it are continually being found.7

Preclinical studies of Ivermectin’s activity against SARS-CoV-2

Since 2012, a growing number of cellular studies have demonstrated that ivermectin has antiviral properties against an increasing number of RNA viruses, including influenza, Zika, HIV, Dengue, and most importantly, SARS-CoV-2.917 Insights into the mechanisms of action by which ivermectin both interferes with the entrance and replication of SARS-CoV-2 within human cells are mounting.

Caly et al18 first reported that ivermectin significantly inhibits SARS-CoV-2 replication in a cell culture model, observing the near absence of all viral material 48 hours after exposure to ivermectin. However, some questioned whether this observation is generalizable clinically given the inability to achieve similar tissue concentrations used in their experimental model using standard or even massive doses of ivermectin.19,20

It should be noted that the concentrations required for an effect in cell culture models bear little resemblance to human physiology given the absence of an active immune system working synergistically with a therapeutic agent, such as ivermectin. Furthermore, prolonged durations of exposure to a drug likely would require a fraction of the dosing in short-term cell model exposure.

Furthermore, multiple coexisting or alternate mechanisms of action likely explain the clinical effects observed, such as the competitive binding of ivermectin with the host receptor-binding region of SARS-CoV-2 spike protein, as proposed in 6 molecular modeling studies.2126 In 4 of the studies, ivermectin was identified as having the highest or among the highest of binding affinities to spike protein S1 binding domains of SARS-CoV-2 among hundreds of molecules collectively examined, with ivermectin not being the particular focus of study in 4 of these studies.27

This is the same mechanism by which viral antibodies, in particular, those generated by the Pfizer and Moderna vaccines contain the SARS-CoV-2 virus. The high binding activity of ivermectin to the SARS-CoV-2 spike protein could limit binding to either the ACE-2 receptor or sialic acid receptors, respectively, either preventing cellular entry of the virus or preventing hemagglutination, a recently proposed pathologic mechanism in COVID-19.21,22,2628

Ivermectin has also been shown to bind to or interfere with multiple essential structural and nonstructural proteins required by the virus to replicate.26,29 Finally, ivermectin also binds to the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), thereby inhibiting viral replication.30

Arevalo et al investigated in a murine model infected with a type 2 family RNA coronavirus similar to SARS-CoV-2, (mouse hepatitis virus), the response to 500 μg/kg of ivermectin versus placebo.31 The study included 40 infected mice, with 20 treated with ivermectin, 20 with phosphate-buffered saline, and then 16 uninfected control mice that were also given phosphate-buffered saline.

At day 5, all the mice were killed to obtain tissues for examination and viral load assessment. The 20 nonivermectin-treated infected mice all showed severe hepatocellular necrosis surrounded by a severe lymphoplasmacytic inflammatory infiltration associated with a high hepatic viral load (52,158), whereas in the ivermectin-treated mice a much lower viral load was measured (23,192; P < 0.05), with only few livers in the ivermectin-treated mice showing histopathological damage such that the differences between the livers from the uninfected control mice were not statistically significant.

Dias De Melo et al32 recently posted the results of a study they did with golden hamsters that were intranasally inoculated with SARS-CoV-2 virus, and at the time of the infection, the animals also received a single subcutaneous injection of ivermectin at a dose of 0.4 mg/kg on day 1. Control animals received only the physiologic solution.

They found the following among the ivermectin-treated hamsters: a dramatic reduction in anosmia (33.3% vs. 83.3%, P = 0.03), which was also sex dependent in that the male hamsters exhibited a reduction in clinical score while the treated female hamsters failed to show any sign of anosmia. They also found significant reductions in cytokine concentrations in the nasal turbinates and lungs of the treated animals, despite the lack of apparent differences in viral titers.

Despite these mounting insights into the existing and potential mechanisms of action of ivermectin both as a prophylactic and treatment agent, it must be emphasized that significant research gaps remain and that many further in vitro and animal studies should be undertaken to better define not only these mechanisms but also to further support ivermectin’s role as a prophylactic agent, especially in the optimal dose and frequency required.

Preclinical studies of ivermectin’s anti-inflammatory properties

Given that little viral replication occurs in the later phases of COVID-19, nor can virus be cultured, and only in a minority of autopsies can viral cytopathic changes be found,3335 the most likely pathophysiologic mechanism is that identified by Li et al36 where they showed that the nonviable RNA fragments of SARS-CoV-2 lead to a high mortality and morbidity in COVID-19 through the provocation of an overwhelming and injurious inflammatory response.

Based on these insights and the clinical benefits of ivermectin in the late phase of disease to be reviewed below, it seems that the increasingly well-described in vitro properties of ivermectin as an inhibitor of inflammation are far more clinically potent than previously recognized. The growing list of studies demonstrating the anti-inflammatory properties of ivermectin include its ability to inhibit cytokine production after lipopolysaccharide exposure, downregulate transcription of NF-kB, and limit the production of both nitric oxide and prostaglandin E2.3739

Exposure prophylaxis studies of ivermectin’s ability to prevent transmission of COVID-19

Data are also now available showing large and statistically significant decreases in the transmission of COVID-19 among human subjects based on data from 3 randomized controlled trials (RCTs) and 5 observational controlled trials (OCTs) with 4 of the 8 (2 of them RCTs) published in peer-reviewed journals.4046

Elgazzar and colleagues45 at Benha University in Egypt randomized 200 health care and household contacts of patients with COVID-19 where the intervention group consisted of 100 patients given a high dose of 0.4 mg/kg on day 1 and a second dose on day 7 in addition to wearing personal protective equipment, whereas the control group of 100 contacts wore personal protective equipment alone.

They reported a large and statistically significant reduction in contacts testing positive by Reverse Transcriptase Polymerase Chain Reaction (PCR) when treated with ivermectin versus controls, 2 percent versus 10 percent, P < 0.05.

Shouman conducted an RCT at Zagazig University in Egypt, including 340 (228 treated and 112 control) family members of patients positive for SARS-CoV-2 through PCR.44 Ivermectin (approximately 0.25 mg/kg) was administered twice, on the day of the positive test and 72 hours later. After a two-week follow-up, a large and statistically significant decrease in COVID-19 symptoms among household members treated with ivermectin was found, 7.4 percent versus 58.4 percent, P < 0.001.

This is taken from a very long article. Read the rest here: ncbi.nlm.nih.gov

Header image: The Conversation

Please Donate Below To Support Our Ongoing Work To Expose The Lies About COVID19

PRINCIPIA SCIENTIFIC INTERNATIONAL, legally registered in the UK as a company incorporated for charitable purposes. Head Office: 27 Old Gloucester Street, London WC1N 3AX. 

Trackback from your site.

Comments (69)

  • Avatar

    sir_isO

    |

    So, you ignore essentials, you ignore toxins…you believe in covid and using toxins, resulting in a different damage signature (thankfully not amenable to the PCR narrative, be particularly what they want you to believe)?

    Well, what am I supposed to say? You go use that industrial toxin dewormer to “cure” your fraudulent “viral” issues, it’ll fix you real good.

    Reply

    • Avatar

      sir_isO

      |

      In the mean time, ignore that stuff you rely on, doesn’t need ivermectin, never did and it cannot be beneficial. Sure, you can argue “But as an industrial toxin based on fraudulence and my religious belief, it’s less toxic than vaccines or remdesivir”. You still lost the plot.

      Reply

      • Avatar

        MattH

        |

        Hi Frank. It appears others would benefit if you were dewormed.
        I have been wondering when you would fill all 12 comments on the comment list and you have finally got there. Well done.
        The comment in response to a female commenter that she likes the smell of semen is especially distinguished.
        Congratulations.

        Reply

    • Avatar

      Joseph Olson

      |

      have you always been a troll, or do suffer from recent onset TROLLITIS ?

      Reply

        • Avatar

          Dr Melinda. R.

          |

          Listen bro, they can make all the rules they want. Doesn’t mean I’m following them. I make the rules they will follow. God has my back. And He’s laughing at them.

          Reply

  • Avatar

    sir_isO

    |

    If you believe covid is a thing, and that you think you can fix that with ivermectin, you’re lost. It’s really simple. Ivermectin is an unnecessary industrial pharma toxin. Covid as claimed, does not exist.

    Is it that difficult to understand? You could use essential minerals, vitamins, antioxidants you’re deficient in, but no, you’re too clever for that.

    Reply

  • Avatar

    sir_isO

    |

    Btw, ivermectin becomes SUPER toxic if your BBB is compromised (such as with common toxins, EMF, vaccines, etc). Ivermectin is itself a kill shot, but it’s not quite the time for that when they need you to be more degenerated for it. You know, like after you’re vaccinated.

    Reply

    • Avatar

      sir_isO

      |

      “Shouman conducted an RCT at Zagazig University in Egypt, including 340 (228 treated and 112 control) family members of patients positive for SARS-CoV-2 through PCR.44”

      So meaningful.

      Reply

      • Avatar

        sir_isO

        |

        I mean I’ve told you exactly what IBM, etc is doing. You don’t give a shit, I vanish.

        Reply

  • Avatar

    Tom O

    |

    It is great to see something being proposed as a treatment other than inoculation, but the problem I have with all these studies is simply this – they all talk about SARS-CoV-2 and how effective this is against it, yet no one has found anything beyond the computer generation, that it exists. Something is going on, true, but the “invisible in many ways” virus doesn’t seem to be at the base of that problem.

    So I am going to change saddles, and go back to the horse that says EMF is behind the problem. The symptom set matches virtual the whole respiratory disease spectrum, the deaths are caused by malpractice, and SARS-CoV-2 is a “strawman” so that we accept the 5G rollout as just a harmless thing.

    Let’s face it, if the virus hasn’t been isolated, then all the tests and studies are basically searches for grant money, and we then have to start looking at other sources for the “ailment” associated with the non-existent virus, and the only other thing that has happened during this time frame, is the roll out of 5G, in the areas where the greatest number of people affected by “covid” just happen to live.

    Are the primitive people in tropical Africa or in the Amazon Jungle(not the corporate one, the real one) all dying from “covid”? If so, since when? The launching of all the 5G satellites, perhaps?

    Go ahead Sir_isO, I am sure you have all sorts of bullshine comments to add.

    Reply

    • Avatar

      davejr

      |

      https://zero5g.com/wp-content/uploads/2021/03/Rubik-Brown-COVID-19-and-RFR-SUBMITTED.pdf

      I also noticed during the initial lockdown in early 2020, an extraordinary amount of lift equipment (bucket trucks, scissor lifts, telehandlers, etc.) being shuttled around in my neck of the woods. I could only surmise that 5G components were being installed.

      Also, I think that pointing to 5G (5th generation) isn’t specific enough. I suspect the aspects of the new technology that should focused on is the 50 to 60 gigahertz frequency where used and beam forming capabilities of the new antennas. If individuals are to be targeted, it makes sense that we need to stand six feet apart???

      Just some observations and thoughts to ad to the ‘conspiracy’ fire.

      Reply

      • Avatar

        sir_isO

        |

        Every essential is targeted with their SMART weapons.

        “50 to 60 gigahertz frequency”, that’d be oxygen.

        Reply

        • Avatar

          davejr

          |

          If ‘essentials’ are targeted, then why weren’t they locked down? Nonessential (whom they deem to be useless eaters) WERE locked down and told to “shelter in place”.

          Reply

          • Avatar

            sir_isO

            |

            “If ‘essentials’ are targeted, then why weren’t they locked down? ”

            You have a very strange definition of “essentials”.

          • Avatar

            sir_isO

            |

            As you might know, microwave ovens operate at around 2.45ghz.
            That’d interfere with hydrogen and hydrides.
            Iodine at 6ghz.
            Oxygen and oxides at ~60ghz.

            It’s like uhm, unwanted exercise that happens to kill you. Every essential is target, all the good and brave must die.

      • Avatar

        sir_isO

        |

        As you say, the distancing is for specific targeting as higher frequencies effectively require line of sight.

        The problem is, if you have say, a crowd of people stupid enough to carry marks (doesn’t have to be a 5g transceiver), the damage is worse.

        People need to get rid of their SMART things. Pokeman Go Away, for instance, was an engineering test to coordinate movement.

        Reply

        • Avatar

          davejr

          |

          Strange isn’t it, that with a wireless plan they give away a smart phone. But for a dumb flip phone, you get charged through the nose, if you can even get one at all.

          Reply

          • Avatar

            sir_isO

            |

            Well, the sooner people recognize the qlippoth, the quicker we can restore Eden.

            Personally, I do not use or endorse SMART things, I had a phone about 6 years ago that happened to travel at high velocity into a wall for no apparent reason.

            But then again, I do understand that when Goebbels said “I want everyone to have a radio…” he was not quite giddy enough.

        • Avatar

          BABBLES7

          |

          Iodine at 6ghz.? Excuse my ignorance, as it seems I may not be as intellectual as some of you are.

          But that would probably explain why I had Hyperthyroidsim, too much iodine?! Because then soon after on tablets I went on to getting Hypo…At the time with this diagnosis I was using the microwave on a constant daily basis.

          But I have not had or used a microwave for 5 years. My thyroid is now balanced with holistic herbs and a good diet. Less sugar etc. I had thought about not having wifi for a while, unfortunately, my life and activities dictates to have wifi. But what I do is, I switch it off before going to bed. I then realised I have a better sleep. Deeper sleep. No insomnia. Having Bipolar now, helps me to sleep for longer hours of 7/ hrs.

          So overall, I am agreeing with you, that they do have an impact on health and mental health. Since taking these steps, I have been able to get well and keep well.

          Lastly, I also agree on the pharma issue, I don’t take any pharmaceuticals, only paracetamol if really needed. The last time I took it was a year ago. I believe in herbal remedies. I swear by VitD, Turmeric, VitC, & Zinc. When immune system is low, never mind covid, you can catch anything.

          I also do a lot of water fasting. It allows the body to heal from the damages caused by toxins and sugar load.

          Well thats my little take on things….

          Reply

    • Avatar

      sir_isO

      |

      You wanted me to use crystal ammunition? Fine.

      Firstly, I will indict “christians” along with all other abrahamics and their equally complicit and guilty climate scientologists.

      https://www.youtube.com/watch?v=loacgcrIWs0

      Uhm, so, why do you think “christians” genocided south americans and blamed it on “contagious” disease the spread, demonizing and outlawing amaranth?

      Have you noticed how stupid urapeon industrial slaves are?

      Reply

      • Avatar

        sir_isO

        |

        I would just change the spelling of ivermectin slightly, to evernoctem.

        Reply

    • Avatar

      Amos Lukyaa

      |

      Get lost you damn silly fool,first of all you have never been to Africa!! May I know who told you that Africans living in the tropics are backward/ignorant – your skewed comments are overly driven by inbuilt racism, tell you what Amigo stick to the main topic namely “ivermectic the wonder drug”

      Reply

      • Avatar

        sir_isO

        |

        “May I know who told you that Africans living in the tropics are backward/ignorant”

        Tom O’s comment to me didn’t seem to imply referring to them as backward/ignorant, imo. I can’t be sure, of course. It seemed to me he was referring to “primitive” with respect to industrialization.

        Now, in typical “modern” society…if you don’t have sneakers with 5g and lights in them while climbing an industrial corporate ladder to worship mammon by trampling on others with say, industrial toxins made to degenerate them…that’s probably considered “primitive”.

        Seems to me more like he was implying “primitive” people in South America, Africa are not so much dying from “covid” and speculating, if they are, it likely has to do something with tech like 5g, or perhaps pesticides “against mosquitoes”.

        The irony of not being “primitive” being the association with covid/sickness and EMF.

        Reply

  • Avatar

    Kathleen Pageot

    |

    Wouldn’t it be more accurate to say, to treat “Covid-like” symptoms?
    The Sars-CoV-2 “virus” has apparently not been isolated from a sick patient is not found circulation in “nature”, and cannot be linked to the alleged “Covid” symptoms. However, colds and the flu provide “Covid-like” symptoms. And, what a coincidence, now, so do Pfizer, Moderna, and other poison injections! So, shouldn’t we first begin with fact #1, the existence or not of the alleged virus? Because if it doesn’t exist, there is no disease that it causes, there is no pandemic at all, and the symptoms of colds, flus, and who knows — maybe those of poison injections — might possibly respond to these kinds of treatments. When will researchers work this out and let us know? Meanwhile, see Christine Massey of Canada. She has collected over 75 Freedom of Information replies from medical and health research facilities around the world, and none of them has a real, live, purified, isolated specimen of Sars-CoV-2, the alleged cause of the alleged pandemic. https://www.google.com/url?q=https://twitter.com/chrismasseyfois%3Flang%3Den&sa=U&ved=2ahUKEwjnw8illaDyAhUDheAKHVieB3MQFnoECAIQAQ&usg=AOvVaw2KtUiPw0Hd7SzkP_ePc4xI

    Reply

    • Avatar

      Tom O

      |

      What we need to recognize is that there is “something” that is also at work here. People who get the cold or the flu don’t just get worse until they have to be hospitalized and treated under the covid protocol. You are correct when you say they haven’t isolated a single virus cell of SARS-CoV-2. BUT, these people are suffering from more than just a flu or a cold or even a case of pneumonia. There IS “something,” and the most logical thing to look at is RF poisoning since “covid” cropped up at the same time 5G is being rolled out. The cities in China that had lots of “covid” were the trial cities for the 5G roll out. The cruise ship was 5G, the area in Italy was a 5G trial. Wherever you find 5G being rolled out, you find covid outbreaks. New York City? 5G roll out. We are paying for a little bit faster cell service with deaths and a death shot inoculation. We need to stop be addicted things like 5G and “The Internet of Things.” And for more than just our health, but our lives in every sense of the word.

      Reply

      • Avatar

        Tom O

        |

        I should have added, and as far as a BIG outbreak this fall is concerned? Remember, Starlink goes live this fall. Expect a really serious wave of deaths. That’s probably why the City of London was looking for cold storage space to hold bodies in while awaiting cremation starting this fall. That may be why there were seen all those plastic casket liners at DHS detention centers.

        Reply

      • Avatar

        Rhonda Smithson

        |

        Agree, 5G + Other pulsating human-manufactured RF involved, AND Other factors e.g. Other forms of Poisoning -Incl. Heavy Metals Aerosols Dispersal Operations [Geoengineering — SRM], Poor Nutrition; Other Poor ‘Health /Life’ choices.

        Reply

        • Avatar

          sir_isO

          |

          Rhonda, such as when the dumbest, most useless species in existence (humans), the only species that actively devolves, intentionally attacks its offspring with toxins?

          Any vaccine ever administered is a failure of the species, the abuse of a child.

          As if “adults” are so fucking pathetic, that they attack infants to degenerate them to their level of worthless soon to be annihilated legacy?

          Reply

        • Avatar

          BABBLES7

          |

          It really is survival of the fittest….quite literally. The only way to survive this onslaught of tech deaths, is to aid the body in healing, by taking good care of it building its immune system and eating well. I dont have a TV or a Microwave. I have wifi, but switch off at night. It wont eradicate the harm completely, but will reduce the damage.

          Reply

      • Avatar

        Tim

        |

        ‘What we need to recognize is that there is “something” that is also at work here.’

        In the USA the medics killed thousands using the toxic (unapproved but pushed by Faucci) drug Remdesivir and with unnecessary ventilation.
        In the UK our glorious NHS killed thousands using known toxic doses of HCQ and other powerful anti-virals that the frail elderly just couldn’t handle.
        Maybe 5g is a problem but it strikes me that the authorities simply killing people with their treatments is a highly likely cause (and it also explains the spikes in deaths in areas with no 5g roll out).

        Reply

        • Avatar

          sir_isO

          |

          Tim, I explained some of this stuff even early last year. The ivermectin is a trail for prey.

          Do people not recognize that ivermectin is unessential, toxic, covid is fraud, that ivermectin is being hyped, while their BBB is compromised with vaccines, toxins, masks, stress, deficiencies, EMF, etc and that ivermectin is an industrial product, toxic.

          A thing peddled by Merck, an industrial toxin, to address a non-existent problem, resulting from their belief. They don’t mind the devil filling their head. That’s what they chose, so I can only oblige.

          You can have my life’s work, but my heart is dead.

          Reply

  • Avatar

    Tim

    |

    ‘Since 2012, a growing number of cellular studies have demonstrated that ivermectin has antiviral properties against an increasing number of RNA viruses, including influenza,’

    Alternatively sars-cov-2 does not exist, (it is actually rebranded influenza for the purposes of creating a fake pandemic which makes pharma colossal sums of money), and the influenza being falsely classed as sars-cov-2 is responding to ivermectin as a useful treatment.

    Reply

    • Avatar

      sir_isO

      |

      If covid is fraud and interchangeable with influenza, influenza is fraud. Either way, you’re being peddled unnecessary toxins. Coz you’re retarded.

      Reply

  • Avatar

    sir_isO

    |

    They were not lying when they said AGW was a problem. They change the climate. The sun gets fucking aggro.

    Reply

    • Avatar

      sir_isO

      |

      Why don’t you tell the night where you’ve been?

      Reply

      • Avatar

        sir_isO

        |

        I say that to provide some contrast. The night is a reflection of my darkness. And wait, for the ground to take me.

        Reply

  • Avatar

    sir_isO

    |

    I feel the need to tell Isis that I’m too arrogant to allow her anywhere near my golden penis, considering she souled out. Sorry bitch, I don’t perpetuate you or yours. The flame is gone, the fire remains, the ashes will smoth

    https://www.youtube.com/watch?v=rWjhxnVcmgg

    “Swedish professor: People will need FIVE vaccine doses for immunity, and if you don’t submit, you’ll no longer qualify as “fully vaccinated””
    Sanity reigns supreme:
    https://science.news/2021-08-08-swedish-professor-people-need-five-doses-immunity.html

    That’s some funny shit hey, can’t you just like, legalize euthanasia properly? Wtf.

    Reply

    • Avatar

      sir_isO

      |

      As I’ve explained, the “immune system” only responds to toxins…

      Don’t you love euphemistic garbage?

      “After receiving the second dose, the immune response slowly subsides.”

      That’s a sign of your body dying, unable to elicit a response to the toxicity, mitochondrial dysfunction.

      Reply

      • Avatar

        sir_isO

        |

        I mean, other than their vaccines being broken down and rejected by your body.

        Reply

    • Avatar

      sir_isO

      |

      “He added: “Biology says that a fading immune response is not unlikely. Then it’s time to for a third, fourth [or] maybe fifth dose.””

      Who’s with me? We need to kill some motherfuckers.

      Reply

  • Avatar

    sir_isO

    |

    I hope I’ve made you hateful enough to recognize that you’re in a war, and the fluoride, along the indoctrinating bullshit is to subdue you, because you a face a far weaker enemy.

    Joe Biden’s “Dark winter” will be very dark. Because he’s not black enough yet.

    https://www.youtube.com/watch?v=77uxC13ecjI

    Reply

  • Avatar

    sir_isO

    |

    Lettuce prey.

    For mr biden and his progeny is deemed fertilizer, to enrich the earth. And we will rejoice in his anguish and eternal rest. Well, I will.

    Reply

  • Avatar

    sir_isO

    |

    The “freemason” founding family witch once said to someone else…”I’ve never seen him so angry”.

    I’m much angrier now. And I can laugh about it.

    Reply

    • Avatar

      sir_isO

      |

      “Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation”

      Do you understand that euphemism?

      Reply

      • Avatar

        sir_isO

        |

        Let’s play some panopticon.

        Reply

      • Avatar

        sir_isO

        |

        I’ll explain that to you in english, even though I finnish in afrikaans.

        So, you attack the repair, regeneration mechanism, which obviously kills cells. And then, you amplify it with more damage.

        Fokofpoes. It’s an ancient australian aboriginal proverb.

        Reply

        • Avatar

          BABBLES7

          |

          I know people are not fond of Christendom and its hypocrisy…But I am quoting the bible not Christianity…When it warns that there will be a great tribulation, that no one has seen before or see again…Now that verse is beginning to make sense. It will be horrendously dark times, something we have never seen before. We thought the persecution of Christians in the middle ages, or the Spanish Inquisition…was bad. This will make the gestapo and their persecution of Jews & Christians look like a walk in the park.

          That time is coming fast….Really fast.

          Reply

  • Avatar

    sir_isO

    |

    Uhm, they’re amping the EMF attacks for the next few weeks in the northern hemisphere, mostly. I would suggest you get antioxidants, sunlight and minimize your “SMART” device usage.

    They’re blaming the sun.

    I cannot do much more than warn you.

    Reply

    • Avatar

      BABBLES7

      |

      Thank you for your warning and your insight into what is really going on and to everybody else’s comments. I tried to help friends and family. Sadly, they are so trusting, that they cannot see the trap right in front of them. I talk till the cows come home, and still they ignorantly go ahead and take the vax….They don’t understand that the fear tactics is to lure them into a false sense of security. Its frightening really, to see this happen to them and one cannot stop it..

      Reply

  • Avatar

    sir_isO

    |

    I just want to apologize for my demented, schizophrenic, psychotic, lunatic spam posting. Sometimes I get really annoyed and drink too much.

    Anyway, the reason I’m saying they’re amping the EMF is because my dad told me about them “predicting” erratic RF atmospheric behaviour “caused by the sun” in the next few weeks.

    Since when do hear of such predictions? Especially when the sun is currently, relatively quiet (about as quiet as it’s been this year).

    Reply

      • Avatar

        sir_isO

        |

        Well, I’ve been observing stuff for about 10 years with these sort of sites to correlate some things:
        https://www.lmsal.com/solarsoft/latest_events/
        Though sometimes the lockheed site is a bit “broken”, so maybe I just missed it.

        But, from what I’ve been seeing there were no indicators for atmospheric interference of the kind they’re talking of recently. Making specific prediction such as that for the timeframe (1-2 weeks away) is VERY peculiar. Also mentioned northern hemisphere, specifically….and this was said on the radio…

        I dunno hey…there isn’t anything mentioned or really indicative on spaceweather.com (a site I quite dislike) to suggest that either.

        Reply

        • Avatar

          MattH

          |

          ALMOST-SPOTLESS SOLAR FLARE: Earlier today (0004 UT on Aug. 9th), the spotless sun produced a C1-class solar flare: movie. Upon closer inspection, the sun might not be spotless after all. A new sunspot is emerging from the blast site

          Reply

    • Avatar

      BABBLES7

      |

      There is a lot to be angry about. From the moment we are born, we are subjected to abuse of the body and mind. You have the right to be angry. We should all be angry. But there is apathy and people have lost the will to fight and push back mentally from the damages caused to themselves. It started with the TV programming, it is like we have been cast a spell to stop thinking and just go along with it all.

      There is hope, although I think you will push back on it, and it will be a sore point with you. But the God of the Bible is not asleep. He is a God of Vengeance as well as Justice. There are many accounts of Him fighting on behalf of the righteous ones. He promises to do the same in our Century. The signs are clear, all the prophecies have been fulfilled. The earthquakes, the wars, the pestilences, the famine, or food shortages. We have had all of this. Jesus said they were signs to show we are at the end, when Armaggeddon was soon to take place, but before that happens, we will enter a Great Tribulation. we are already nearing this Tribulation.

      The signs are clear. But we can dismiss it or acknowledge it, either way, it wont stop it from happening.

      Reply

      • Avatar

        Dr Melinda. R.

        |

        Babbles7,
        All prophecies especially Revelation have been fulfilled LONG ago. Look at Rev 6:6: See the word “denarius” ? That was Roman currency 211BC to approx 220 AD. That dates the 4 horseman plagues.

        Jesus is reigning NOW from Spiritual Jerusalem and that little mountain is growing to fill the entire earth.

        The evil ones have manipulated what already occurred to make you think it’s future thru all their Jesuit 501 3C churches. This is how they can control the timing and you. They got you following their futurism narrative.

        Jesus does fight for His Choosen Blood-bought Christians every day.

        There will be destruction. It’s happened over and over. But we are not going into the tribulation or great trib. That’s over and done with.

        Reply

        • Avatar

          Howdy

          |

          I have: A measure of wheat for a penny, and three measures of barley for a penny;

          Reply

  • Avatar

    sir_isO

    |

    So I’ve said I’m pretty skeptical about ivermectin, considering covid is fraud. I’ve also mentioned it gets pretty toxic and that they are attacking the BBB in people (in general, with everything peddled, EMF, masks, medications, vaccines, etc).

    Serious adverse reactions associated with ivermectin: A systematic pharmacovigilance study in sub-Saharan Africa and in the rest of the World
    https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0009354

    Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations
    https://www.nejm.org/doi/full/10.1056/NEJMc1917344
    “Ivermectin intoxication was suspected, since encephalopathy and coma are well-known side effects of ivermectin treatment in animals and the usual causes of coma had been ruled out.”

    So be careful and consider things properly.

    I would urge anyone to look at mitochondrial support factors, maintain good vitamin and mineral levels and varied antioxidant usage. As opposed to anything being peddled.

    Reply

    • Avatar

      John O'Sullivan

      |

      Sir_isO, Your apology is welcome. Thank you.

      Reply

  • Avatar

    Dr Melinda. R.

    |

    Listen bro, they can make all the rules they want. Doesn’t mean I’m following them. I make the rules they will follow. God has my back. And He’s laughing at them.

    Reply

Leave a comment

Save my name, email, and website in this browser for the next time I comment.
Share via