Bivalent Vaccines Up to Bat: a Swing and a Miss
The US government vaccine program led by the CDC and FDA selected mRNA vaccines that contained genetic code for the original (long extinct) Wuhan wild-type strain (50 percent) and Omicron BA4/BA5 subvariant (50 percent).
These products were purchased before the failed animal studies were completed.
The FDA who is conflicted as a sponsor of the vaccine program, approved the products based upon a surrogate antibody elevation against BA4/BA5.
Within a few short months, as depicted by the CDC Nowcast system, BA4/BA5 are on their way out giving way to BQ.1 and BQ1.1.[i]
This has been an accurate and helpful part of the CDC’s effort to inform the public and scientists on the outbreak:
“To identify and track SARS-CoV-2 variants, CDC uses genomic surveillance.
CDC’s national genomic surveillance system collects SARS-CoV-2 specimens for sequencing through the National SARS-CoV-2 Strain Surveillance (NS3) program, as well as SARS-CoV-2 sequences generated by commercial or academic laboratories contracted by CDC and state or local public health laboratories.
Virus genetic sequences are analyzed and classified as a particular variant.
The proportion of variants in a population are calculated nationally, by HHS region, and by jurisdiction.
The thousands of sequences analyzed every week through CDC’s national genomic sequencing and bioinformatics efforts fuel the comprehensive and population-based U.S. surveillance system established to identify and monitor the spread of variants.”
So Nowcast is telling us the emerging dominant strains are BQ.1 and BQ.1.1 subvariants, known to have enhanced ability to fuse with the human ACE-2 receptor, dictated by the N460K mutation which is the principle site for antibody neutralization.[ii]
Qu et al have recently demonstrated that sera from patients with BA4/BA5 had very poor antibody defenses against BQ.1 and BQ.1.1.
The authors concluded:
“The perpetual emergence of SARS-CoV-2 variants with enhanced immune escape continues to threaten public health.
Monitoring the immune escape of emerging variants will be critical to improving mRNA vaccine reformulation, assessing new broader coronavirus vaccine candidates, as well as directing ongoing public health measures.”
This is a politically correct way of saying the new vaccines are essentially obsolete just a few months after their debut.
Is it possible the bivalent vaccines prompted this mutational shift? Given the low public (<10.1 percent) uptake, it is unlikely they have applied ecologic pressure on the virus.
To summarize, the US government just stuck out with a big expensive swing and a whiff against SARS-CoV-2 mutating away with BQ.1/BQ.1.1!
References
[i] CDC Nowcast System Accessed November 14, 2022
[ii] Qu P, Evans JP, Faraone J, Zheng YM, Carlin C, Anghelina M, Stevens P, Fernandez S, Jones D, Lozanski G, Panchal A, Saif LJ, Oltz EM, Xu K, Gumina RJ, Liu SL. Distinct Neutralizing Antibody Escape of SARS-CoV-2 Omicron Subvariants BQ.1, BQ.1.1, BA.4.6, BF.7 and BA.2.75.2. bioRxiv [Preprint]. 2022 Oct 20:2022.10.19.512891. doi: 10.1101/2022.10.19.512891. PMID: 36299423; PMCID: PMC9603827.
See more here substack.com
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VOWG
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Idiots in government are the biggest threat to our health.
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aaron
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I would say the people who believe in the need of govts and the superstition of authority are the biggest threats not only to our health but to our existence.
Governments have never been good for the people they supposedly serve, who needs that.
A bit of interesting reading:
https://www.scribd.com/doc/86174715/The-Most-Dangerous-Superstition-by-Larken-Rose
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Tom
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Name me one vaccine over the last 50 years that was an unmitigated proven “hit” that saved lives and didn’t cause a inverse reaction that actually helped spread the virus it was supposed to prevent from spreading.
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Carbon Bigfoot
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US House Panel Discussion chaired by Bulldog Rep.. Chip Roy who IMHO should be the next Speaker of the House. Two hours plus covering numerous topics with witnesses.
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aaron
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that is what we need, more sideshows, enjoy the circuses!
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Doug Harrison
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How can they say they are seeing genomic variations when nobody has ever seen an identifiable virus? In spite of the nobel prize being awarded to the evil con man Dr Nelson Flexner who actually said he was not certain that he did find a virus and identify it. When you are the head of the Rockefeller Foundation’s medical research arm, anything you say becomes gospel truth.
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Charles Higley
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NO one mentions that the new strains of a coronavirus are patently more infective but also less virulent, less deadly, with their goal being to become virtually harmless and thus immortal. Tracking these new strains is a joke as it perpetuates the fear-mongering of Covid -19 which was not even 1/10th as deadly as normal flu.
This is a total propaganda scamdemic produced by the government and big pharma, using the jabs to destroy human health, which is why they will push new jabs until they achieve the desired destruction.
Imagine what will happen when the people of the world figure out what is being done to them. Some will figure it out.
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Jakie
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Let the Dim Bulbs of the world UNITE!
There’s Safety in Numbers, Right?
Heh, HEH, HEH!!!
They’ll never wake up, even as the deaths accelerate all around them. The Hypnotism programming is deeply imbedded after decades of TV frequency Entrainment.
A Quite Earth approaches.
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