Australian COVID 19 DNA vaccine needle-free trial commences
Led by the University of Sydney, Scientia Clinical Research (Sydney), Telethon Kids Institute (Perth) and the Women’s and Children’s Hospital (Adelaide), the COVALIA trial uses a gene-based vaccine with DNA sequences from the SARS-CoV2 virus.
The researchers have partnered with Australian biotech company Technovalia and its international vaccine partner BioNet who developed the DNA vaccine. It uses similar technology to other genetic vaccines, like mRNA, in use in Australia and internationally.
Gene-based vaccines use genetic (DNA) sequences from the virus. Researchers identify and isolate parts (genes) of the virus genome. Once the DNA is inside the cell the body uses the DNA code to make the coronavirus spike protein trigger an immune response.
This potential next-generation vaccine has no additives or preservatives. It will be given using a needle-free device that penetrates the skin with a jet spray and is designed to make sure the vaccine gets inside the cells to encourage good uptake by the immune system.
While not approved outside research studies in Australia, this needle-free device is already being used to give influenza vaccines in the United States.
About the Phase 1 trial
The Phase 1 trial will recruit 150 participants with screening and enrolments of participants now open.
The key goal is to examine the safety of two doses of the vaccine given one month apart. If the trial is successful, then a larger phase 2 trial will be undertaken.
The trial will also look at whether a lower vaccine dose may work better following vaccination into the skin rather than muscle, which is important as it could enable more people to be vaccinated with the available vaccine supply.
Lead Investigator Associate Professor Nicholas Wood from the University of Sydney said: “We are very excited to start enrolment along with our colleagues in Perth and Adelaide, and to undertake the first needle-free COVID vaccine trial in Australia. The start of the COVALIA study is a significant milestone for all involved in this one-of-a-kind partnership between Australian institutions, the industry and the Australian Government with $3 million in funding from the Medical Research Future Fund (MRFF).”
Co-Investigator Professor Peter Richmond from the Telethon Kids Institute said, “It is really important that we continue to develop the next generation of COVID-19 vaccines, as we may see even better safety and immune responses. Having a greater range of vaccines available increases global vaccine capacity to ensure everyone has access to immunisation.”
Co-Investigator Professor Helen Marshall from the Women’s and Children’s Hospital and The University of Adelaide said “It’s a great opportunity for Australians to contribute to developing safe and effective COVID vaccines for the Australian population, and especially as it’s a needle free vaccination.”
See more here: sydney.edu.au
Header image: Pharmajet
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Howdy
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Dammit Jim I’m a medical device, not a tyre inflator!
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very old white guy
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Is this supposed to make people fell better about taking poison?
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Russell Haley
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This is a blatant, obvious ploy to get new DNA gene therapy technologies approved. It has nothing to do with covid inoculation. There is no way this sh&* would have flown prior to this covid debacle. Everyone – and I mean everyone – knows this is a once in a lifetime opportunity to push through dangerous technologies with minimum oversight.
This announcement has also been timed to lessen the damage done when governments finally start admitting that the current vaccines are a complete failure. “Oh, well, those ones failed. But we have a new one right here that will totally work this time. We promise…”
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Tom
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Another attempt to get people to think positively about allowing a poison injection into their bodies.
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Doug Harrison
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To quote from the article: the COVALIA trial uses a gene-based vaccine with DNA sequences from the SARS-CoV2 virus.
I am not a virologist but as far as I know a virus does not have a genome and is just a particle of RNA and only becomes a living thing after it infects a host cell and takes up the genome from that cell. If I am wrong then please somebody explain where I am wrong in language that is easily understood by a layman.
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Protestant
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After looking for more information about this new “needle-free” invention, I was surprised to find that it was actually developed in the 1960s for the mass vaccinations against polio!
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Protestant
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Sorry, I meant the “smallpox” vaccine, the one that left a scar on your arm from the jet spray gun, not the polio sugar cubes or later injections.
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Mervyn
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Why do they have to use this technology? We’re told there is a covid pandemic. That being the case, why don’t these scientists simply use the actual virus to make the vaccine?
The answer is simple. Not-one of these scientists-virologists have isolated the covid virus from which to make a vaccine. America’s CDC has no virus sample. So you can almost be certain nobody else does.
Any virologist who can isolate the covid virus should immediately contact Samuel Eckert.
German journalist Samuel Eckert’s offer of Euros1,5 million to anyone who can provide irrefutable proof of existence of Covid-19 (by isolation of the virus according to ‘Koch’s postulates’) still remains open.
https://www.samueleckert.net/isolate-truth-fund/
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