Study Identifies 10 Major Flaws in COVID-19 PCR Tests
External peer review of the RTPCR test to detect SARS-CoV-2 reveals 10 major scientific flaws at the molecular and methodological level: consequences for false positive results.
ABSTRACT
In the publication entitled “Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR”
(Eurosurveillance 25(8) 2020) the authors present a diagnostic workflow and RT-qPCR protocol for
detection and diagnostics of 2019-nCoV (now known as SARS-CoV-2), which they claim to be
validated, as well as being a robust diagnostic methodology for use in public-health laboratory
settings.
In light of all the consequences resulting from this very publication for societies worldwide, a group
of independent researchers performed a point-by-point review of the aforesaid publication in which
1) all components of the presented test design were cross checked, 2) the RT-qPCR protocol-
recommendations were assesses w.r.t. good laboratory practice, and 3) parameters examined
against relevant scientific literature covering the field.
The published RT-qPCR protocol for detection and diagnostics of 2019-nCoV and the manuscript
suffer from numerous technical and scientific errors, including insufficient primer design, a
problematic and insufficient RT-qPCR protocol, and the absence of an accurate test validation.
Neither the presented test nor the manuscript itself fulfils the requirements for an acceptable
scientific publication. Further, serious conflicts of interest of the authors are not mentioned. Finally,
the very short timescale between submission and acceptance of the publication (24 hours) signifies
that a systematic peer review process was either not performed here, or of problematic poor quality.
We provide compelling evidence of several scientific inadequacies, errors and flaws. Considering the
scientific and methodological blemishes presented here, we are confident that the editorial board of
Eurosurveillance has no other choice but to retract the publication.
Review Report – Corman-Drosten et al., Eurosurveillance 2020
CONCISE REVIEW REPORT
This paper will show numerous serious flaws in the Corman-Drosten paper, the significance
of which has led to worldwide misdiagnosis of infections attributed to SARS-CoV-2 and
associated with the disease COVID-19. We are confronted with stringent lockdowns which
have destroyed many people’s lives and livelihoods, limited access to education and these
imposed restrictions by governments around the world are a direct attack on people’s basic
rights and their personal freedoms, resulting in collateral damage for entire economies on a
global scale.
There are ten fatal problems with the Corman-Drosten paper which we will outline and
explain in greater detail in the following sections.
The first and major issue is that the novel Coronavirus SARS-CoV-2 (in the publication named
2019-nCoV and in February 2020 named SARS-CoV-2 by an international consortium of virus
experts) is based on in silico (theoretical) sequences, supplied by a laboratory in China [1],
because at the time neither control material of infectious (“live”) or inactivated SARS-CoV-2
nor isolated genomic RNA of the virus was available to the authors. To date no validation
has been performed by the authorship based on isolated SARS-CoV-2 viruses or full length
RNA thereof.
According to Corman et al.: “We aimed to develop and deploy robust diagnostic
methodology for use in public health laboratory settings without having virus material
available.”[1]
The focus here should be placed upon the two stated aims: a) development and b)
deployment of a diagnostic test for use in public health laboratory settings. These aims are
not achievable without having any actual virus material available (e.g. for determining the
infectious viral load). In any case, only a protocol with maximal accuracy can be the
mandatory and primary goal in any scenario-outcome of this magnitude. Critical viral load
determination is mandatory information, and it is in Christian Drosten’s group responsibility
to perform these experiments and provide the crucial data.
CONCLUSION
In light of our re-examination of the test protocol to identify SARS-CoV-2 described in the Corman-Drosten paper we have identified concerning errors and inherent fallacies which render the SARS-CoV-2 PCR test useless.
The decision as to which test protocols are published and made widely available lies squarely
in the hands of Eurosurveillance. A decision to recognise the errors apparent in the Corman-
Drosten paper has the benefit to greatly minimise human cost and suffering going forward.
Is it not in the best interest of Eurosurveillance to retract this paper? Our conclusion is clear.
In the face of all the tremendous PCR-protocol design flaws and errors described here, we
conclude: There is not much of a choice left in the framework of scientific integrity and
responsibility.
Download the full PDF of the paper at www.researchgate.net
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Saeed Qureshi
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The following would be of interest and support in this regard http://www.drug-dissolution-testing.com/?p=3650
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tim
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anyone got any info on the latest court action against drosten concerning this farcical pcr test. it was featured on this site nearly a month ago but i have heard nothing since. surely if this test can be shown in court that it is useless then we could have the start of the domino toppling effect against this covid scamdemic. i know that reiner fuellmich was the guy behind the lawsuit against drosten and that the legal papers were filed with a cease and desist order against him but no news since then.
this is so important to start getting this madness stopped
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