Post-COVID Syndrome Associated with Persistent Spike Protein

Written by Peter A. McCullough, MD, MPH on March 14, 2023. Posted in Current News

Approximately half of patients hospitalized mainly in 2020 and 2021 with acute COVID-19 had post-COVID symptoms for weeks afterward

Craddock et al measured both viral RNA and Spike protein in 116 patients hospitalized with COVID-19 at the University of Kansas.

Follow-up was not standardized and had most at 8-12 weeks and some out to 24 weeks with information (PASC=post-COVID symptoms).

They found that measurement of viral RNA and Spike protein was valuable in describing a relationship between the presence of post-COVID symptoms (fatigue, lethargy, etc.) and persistent Spike both free and circulating in vesicular particles.

The amount of Spike was most strongly correlated with

1) severity of symptoms in the hospital,

2) duration of hospitalization, and

3) blood d-dimer level.

This study points to the pressing clinical need for the US FDA to grant in vitro diagnostics companies approvals to market blood assays for Spike protein and hopefully both viral and vaccine RNA and mRNA.

In the meantime, there is now support to measure d-dimer in post COVID patients as weak surrogate of circulating Spike.

It is reassuring to patients suffering with post-COVID or “long-COVID” that it is not all in their heads, the pathophysiology is pointing to persistence of Spike protein in the blood which is pathogenic and likely driving tissue/organ injury with associated symptoms.

Because COVID-19 mRNA vaccines further load the body with genetic code and more Spike protein, it is likely that vaccination worsens post-COVID syndromes despite raising antibodies against the Spike protein.

I have not found claims that vaccination reduces long-COVID syndromes valid in bias papers that are pushing vaccines.

See more here substack.com

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