New Study: HCQ Protocol ‘Effective’ Against COVID-19

The International Journal of Antimicrobial Agents has published a new peer-reviewed study which  confirms that low-dose hydroxychloroquine combined with zinc and azithromycin was an effective therapeutic approach against COVID-19.

This is the world’s first COVID-19 outpatient study based on risk stratification and early antiviral treatment at the beginning of the disease. The authors report that the HCQ protocol “Significantly reduced hospitalisation rates in the treatment group” and “reduced mortality rates in the treatment group.”

ABSTRACT

The aim of this study was to describe the outcomes of patients with coronavirus disease 2019 (COVID-19) in the outpatient setting after early treatment with zinc, low-dose hydroxychloroquine and azithromycin (triple therapy) dependent on risk stratification. This was a retrospective case series study in the general practice setting. A total of 141 COVID-19 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the year 2020 were included. The main outcome measures were risk-stratified treatment decision and rates of hospitalisation and all-cause death. A median of 4 days [interquartile range (IQR) 3–6 days; available for n = 66/141 patients] after the onset of symptoms, 141 patients (median age 58 years, IQR 40–67 years; 73.0% male) received a prescription for triple therapy for 5 days. Independent public reference data from 377 confirmed COVID-19 patients in the same community were used as untreated controls. Of 141 treated patients, 4 (2.8%) were hospitalised, which was significantly fewer (P < 0.001) compared with 58 (15.4%) of 377 untreated patients [odds ratio (OR) = 0.16, 95% confidence interval (CI) 0.06–0.5]. One patient (0.7%) in the treatment group died versus 13 patients (3.4%) in the untreated group (OR = 0.2, 95% CI 0.03–1.5; P = 0.12). No cardiac side effects were observed. Risk stratification-based treatment of COVID-19 outpatients as early as possible after symptom onset using triple therapy, including the combination of zinc with low-dose hydroxychloroquine, was associated with significantly fewer hospitalisations.

INTRODUCTION

In December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started as an outbreak in Wuhan, China. This coronavirus has spread rapidly as a pandemic around the world [1],…. As of June 2020, the diagnosis and treatment of COVID-19 have been almost exclusively studied from an inpatient perspective, including intensive care with mechanical ventilation. Only one study has described the characteristics and key health outcomes of COVID-19 diagnosed patients in an outpatient setting [3]….. The early clinical phase of COVID-19 has not been the focus of much research so far, even though timing of antiviral treatment seems to be critical [5]. The optimal window for therapeutic intervention would seem to be before the infection spreads from the upper to lower respiratory tract and before severe inflammatory reaction ensues [6]

…..

4. Discussion

This first retrospective case series study of COVID-19 outpatients in a primary care setting showed that risk-stratified treatment early after onset of clinical symptoms with triple therapy of zinc, low-dose HCQ and azithromycin was associated with significantly fewer hospitalisations (OR = 0.16; P < 0.001) in comparison with untreated patients (public reference data) of the same community.

…. Azithromycin was added to the treatment regimen as preliminary data provided evidence for more efficient or synergic virus elimination in conjunction with bacterial superinfection [13,52]. Although there is a synergistic antiviral effect between zinc, HCQ and azithromycin, zinc supplementation may be instrumental for the outcome of patient populations with severe clinical courses. Zinc deficiency was confirmed in a large number of healthy elderly [53] and in diabetic patients [54]. In addition, it has been documented that the antihypertensive drugs hydrochlorothiazide, angiotensin-converting enzyme inhibitors and angiotensin 2 receptor antagonists can result in increased urinary excretion of zinc with subsequent systemic zinc deficiency [55].

https://doi.org/10.1016/j.ijantimicag.2020.106214

Download/read the full paper at www.sciencedirect.com

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Comments (1)

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    Chris

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    Sounds like a good approach to helping with bacterial pneumonia. That’s the actual problem here, not the common cold. I wish that they would finally come forward with the truth that no lab has been able to find covid19 virus. People who are malnourished are apparently more susceptible to bacterial pneumonia. Antibiotics don’t help with viruses. Misuse of antibiotics can cause antibiotic resistance in bacteria. So if these people are suffering from just a virus then they are not treating them correctly, but like it says these people have bacterial pneumonia, “bacterial superinfection”.

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