Is Chlorine Dioxide Really a Universal Antidote?

Written by Curious Outlier on August 7, 2025. Posted in Current News

This is the third and final article in a series exploring the mechanisms of action of chlorine dioxide in the human body

I will do my best to explain both the established and theoretical mechanisms behind its effects in terms that are easy to understand.

If you have not watched The Universal Antidote documentary, I encourage you to do so.

The documentary provides helpful background information to learn more about this substance and its potential to improve human health and treat disease.

Part 1 in this series on mechanisms of action

Part 2 in this Series on mechanisms of action

For the past three decades, research on the therapeutic effects of chlorine dioxide in both humans and animals has been significantly restricted at most points related to health and disease treatment.

As a result, scientific proof through randomized, placebo-controlled trials has not been established. In light of this, my task as a researcher is to demonstrate chlorine dioxide’s properties as thoroughly as possible, using evidence from the scientific literature and anecdotal testimonials as guidance to enhance understanding of how this substance can be safely and effectively used for the benefit of human health.

Chlorine dioxide’s paramagnetic, +4 to +3, oxidative state categorizes it as an intermediate to mild oxidant. This leads us to hypothesize that chlorine dioxide might share some of the beneficial properties demonstrated by other oxidative therapies, such as ozone therapy, exercise therapy, intermittent hypoxic training, and intermittent fasting.

This third article in the series presents my—and others’—hypothesis regarding the mechanism of action of chlorine dioxide on biological systems and, in turn, its beneficial effects on human, animal, and plant health.

While much scientific research is still needed to fully understand what gives chlorine dioxide its potential as a universal antidote within the human body, this series aims to shed light on what is currently known.

As we progress through the details of this article, I will take short intermissions to share testimonials that exemplify the mechanism of action being addressed. Additionally, at the end of the article after the references, I will share several more astounding testimonials that provide compelling evidence that chlorine dioxide is the closest thing to a universal antidote that we currently have.

Mitochondrial Hormesis

When people with diseases caused by mitochondrial dysfunction (e.g. diabetes, cancer, chronic fatigue, and dementia) take chlorine dioxide, they quite often have a reversal of these problems.

The known mechanism of action for reversing these diseases caused by mitochondrial dysfunction is ROS-induced mitochondrial hormesis. You may be asking yourself, “What the heck is ROS-induced mitochondrial hormesis?” So let’s first start with definitions.

ROS-induced mitochondrial hormesis, also known as mitohormesis, is a biological phenomenon in which a mild, transient increase in mitochondrial reactive oxygen species (ROS) production—or ROS from an outside source—triggers adaptive cellular responses that enhance stress resistance, improve metabolic health, and can extend lifespan. [1]

Rather than being solely damaging, low to moderate levels of ROS act as signaling molecules that activate protective pathways, including upregulation of antioxidant defenses, improved mitochondrial quality control, and enhanced cellular repair mechanisms. [1]

This biphasic, dose-dependent response contrasts with the detrimental effects seen at high ROS concentrations, where oxidative damage prevails.

ROS-induced mitochondrial hormesis and the redox stress response associated with it are highly conserved biochemical reactions that occur across biological life with core mechanisms shared among plants, animals, and other organisms. [9]

Testimonial 1 (Uncontrolled Diabetes)

“Started MMS about a month ago. I have had uncontrollable diabetes for years. I have now reduced my insulin to just a small amount as my sugar levels were dropping too low. After decades of fighting this I am now staying in the normal to upper 100 range where before I was in a greater than 250 average. I am astounded.”

This concept of mitochondrial hormesis challenges the traditional view that ROS like hydrogen peroxide, hypochlorous acid, ozone, and chlorine dioxide are solely harmful and instead suggests that controlled exposure to mild oxidative stress can have beneficial effects and strengthen many aspects of biological systems.

Low, non-cytotoxic concentrations of ROS can serve as important signaling molecules within the cell, activating a variety of cellular pathways. These pathways are involved in critical processes such as mitochondrial biogenesis, the upregulation of antioxidant defense systems, and overall cellular adaptation to stress.

The ability of ROS to function as signaling agents highlights their dual role in both cellular damage and adaptation. [2]

Mitochondrial Biogenesis

One of the key adaptive responses to ROS signaling is the stimulation of mitochondrial biogenesis. When present in moderate amounts, ROS can actually help cells boost their energy production by increasing both the number and efficiency of mitochondria.

Mitochondria are structures often called “the powerhouses of the cell.” ROS do this by raising the levels of special proteins called PGC-1α and PGC-1β. These proteins act as master regulators, turning on the genes needed to build new mitochondria and keep them working well.

At the same time, ROS activate other helper proteins, such as stress-sensitive enzymes and gene-regulating factors, which work together with PGC-1α and PGC-1β to further promote the creation of new mitochondria and enhance their function.

This entire process, known as mitochondrial biogenesis, allows cells to respond and properly adapt to stress challenges by increasing their capacity to produce energy. In this way, a controlled amount of ROS actually helps keep our cells healthy and resilient. [3]

Testimonial 2 (Alzheimer’s)

“After my mother was diognosed with Alzheimers she hated the effects of the pill so much that she was willing to try MMS. Her symptoms disapeared almost over night the next morning after only drinking 6 drops 3 times she told me the story of how she met my father some 60 years before which was impossable the day before.

She continued taking it for a week and then felt so good she stopped taking it within 1 month the symptoms returned after taking MMS again the symptoms went away again. she had to take a daily maintanence dose to keep it at bay.

Thank you Jim Humble you are my Hero, Keith Pace”

An increase in mitochondria within a cell, driven by mitochondrial biogenesis, leads to a range of significant physiological and metabolic changes. First and foremost, more mitochondria enhance the cell’s ability to generate ATP through oxidative phosphorylation, thereby supporting higher energy demands during growth, differentiation, exercise, or cellular repair. [4]

This boost in mitochondrial content also improves cellular metabolism by increasing metabolic flexibility, allowing cells to oxidize fatty acids and glucose more efficiently. As a result, there is often a shift toward greater fatty acid oxidation, reduced reliance on glycolysis, and improved overall energy efficiency. [5]

Additionally, mitochondrial biogenesis serves as an adaptive response to various stressors, such as oxidative stress, caloric restriction, and physical activity. By increasing mitochondrial content, cells become better equipped to cope with increased energy demands or to recover from damage.

In tissues that are highly dependent on aerobic metabolism, such as muscle and neurons, this increase helps maintain cellular function and promotes survival, particularly under conditions of stress or injury. [5,6]

Testimonial 3 (Dementia)

“I can tell you our experience with dementia. My 83 yr young mother-in-law has it. She has been on MMS since December 18th. She is doing 3 drops with DMSO now. She was unable to dress herself, clean up after an accident, and there were many. She couldn’t hold any conversations. She wasn’t reading etc… She now makes her bed, folds her clothes, dresses her self.

No more accidents. She is reading and doing her word searches. She is able to remember what day it is sometimes plus bits and pieces from previous conversations. She can carry a small 10/15 minute conversation now. All of this in just 3 months. Not to mention she is off her dementia medication, her high blood pressure medication, her diabetes is getting closer to pre diabetes vs. type 1. She has come a very long way.”

Link to original testimonial

The balance between mitochondrial biogenesis and mitophagy (the removal of damaged mitochondria) is also crucial for regulating cell fate and maintaining mitochondrial quality. Proper regulation of these processes supports overall cellular health, while dysregulation can contribute to disease or cell death. [4,10]

Notably, increased mitochondrial biogenesis has been associated with healthier aging, improved insulin sensitivity, and greater resistance to metabolic and neurodegenerative diseases, as it helps maintain cellular energy homeostasis and reduces the accumulation of dysfunctional mitochondria. [5,11]

In summary, an increase in mitochondria equips the cell with enhanced bioenergetic capacity, metabolic adaptability, and resilience to stress, all of which are essential for optimal cellular health and function.

Upregulation of Antioxidant Defense Systems

Mild oxidative stress occurs when cells experience a small increase in ROS, which are molecules that can both damage cells and act as important biological signals.

At low levels, ROS activate special proteins called transcription factors, like NRF2, that turn on genes responsible for producing antioxidant enzymes such as superoxide dismutase (SOD) and catalase.

These enzymes help protect cells by breaking down harmful molecules and maintaining antioxidant/oxidant balance. [12,13,14]

This process is an example of hormesis, where a mild stress makes cells stronger and better prepared for future challenges. When cells are exposed to a small, non-harmful amount of oxidative stress, they temporarily increase their antioxidant defenses.

This adaptive response not only activates existing enzymes but also boosts the production of new protective proteins, helping cells survive more severe oxidative damage later on. [15,16,17]

Testimonial 4 (Chronic Fatigue)

“I’ve healed my osteoarthritis, TMJ on my right side jaw, allergies are gone, pain and fatigue are greatly reduced, I have more energy than I’ve had in a long time, the tell tale butterfly rash of lupus is almost gone now, CFS/Fibromyalgia is greatly reduced, I’ve slimmed down 18 pounds (thanks to the Mold & Fungus Protocol), I rarely suffer any headaches/migraines (unless there’s a fast moving storm coming in and very high barometric pressure too – tell me I still have heavy metals in my head from military vaccines), etc.

This is in 10 months of doing CD. I still have a way to go, you don’t reverse 20+ years of harm in just a few months. I do use a few binders, to help me detox as I don’t do that very efficiently without help.

The best advice I can give you is to take things low and slow, and don’t be afraid to get comfortable with one thing and not look at the Supporting Protocols to help things along.

With me and my son we do several, and it’s working out really well for the both of us, even if healing takes it’s time, this is a marathon not a sprint (@CuriousOutlier is always saying this to people). You never compare yourself to other people, you compare yourself to your former self.”

Link to original testimonial in telegram private chat

If you are not a member of the private chat and want to see this testimonial, you can use this join link.

Research in animals, plants, and other organisms shows that mild oxidative stress triggers a “preparation for protection” response. This means that cells purposely increase their antioxidant enzymes and other defensive mechanisms to clean up damaged molecules and improve survival. This intrinsic response is seen across many species and helps organisms better handle future oxidative stress, making it a key part of how living things maintain health under changing conditions. [15,16,17,18]

Low-Level Reactive Oxygen Species and Autophagy

Autophagy is the process in which a cell breaks down and recycles its own damaged or unnecessary parts to keep itself healthy and functioning well. [19]

ROS play an important role in triggering autophagy, which is the process cells use to clean out abnormal proteins, damaged organelles, invading microorganisms, etc. One way ROS do this is by directly affecting a protein called Atg4.

This protein is essential for autophagy. When ROS oxidize Atg4, they change how the protein works, making it easier for the cell to start forming autophagosomes, which are structures that help remove unwanted material. [20]

ROS also activate several key signaling pathways that lead to autophagy. For example, they turn on AMPK, a protein that then shuts down mTOR, a major blocker of autophagy. This allows the cell to start building autophagosomes.

Additionally, ROS can activate certain transcription factors, which are proteins that help turn on genes involved in autophagy, like BNIP3, LC3, and p62.

ROS can also disrupt the interaction between two proteins, Bcl-2 and Beclin-1, which further help the autophagy process. [21, 22, 23]

Testimonial 5 (Parkinson’s Disease & Cognitive Decline)

Extracted from an Italian Audio Testimonial, voice-to-text, then translated from Italian to English. (Link to original Italian Audio Testimonial)

“Regarding my 81 year old mother, a strong clinical picture of Cognitive Degeneration and Parkinson’s Disease.

Until a month ago mother was as if closed in a world of her own, very mute, completely devoid of any emotion, devoid of expression. After the first week of taking CDS eight times a day in a little water with a very low dosage, I think 5 ml, after the first week my son and I have already noticed the first incredible improvements, precisely regarding speech. That is mother who didn’t speak, began to make long speeches, remembering things from 50 years ago.

Today after just over a month of treatment, we have reached 10 ml of CDS a day, and mother is a completely different person. She walks in a much more upright position, she no longer rubs her feet, and she helps me do the housework.

Two months ago, she was completely non-self-sufficient and today, for example, she empties and loads the whole dishwasher for me.

She gets up every hour to get herself the CDS. Another aspect that was absolutely unthinkable a month ago because mother was in bed all day. So for me it was unthinkable that she could get up, go to the kitchen, take the CDS out of the fridge, pour it into the cup, add water… unthinkable.

I bought her an album of mandalas, she colors them.

And the other incredible aspect is that I am slowly reducing her medicines, the triptych, the one for depression that she took in the evening… as well as the Sinemet which is a medicine for muscle stiffness.

So I am shocked after only a month by the incredible miraculous results and she is very happy, and we will take CDS for life, that’s for sure.”

This is taken from a long document, read the rest here substack.com

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