Gene Therapy: Did We Open Pandora’s Box?
Jesse Gelsinger, 18, had a rare metabolic disorder called ornithine transcarbamylase deficiency syndrome, or OTCD, in which ammonia builds up to lethal levels in the blood. He managed the condition with a low-protein diet and a regimen of nearly 50 pills a day.
In 1999, Gelsinger volunteered to participate in a gene therapy trial with the hope of helping others with the same disease. However, a few days later, he became the first person to die as a result of a gene therapy experiment.
The potential OTCD treatment was to inject a genetically modified and weakened adenovirus vector into the patient’s liver, and to introduce the normal ornithine aminome thyltransferase gene (OTC gene) into the patient’s liver chromosomal DNA, to restore the liver’s ability to metabolize ammonia.
Gelsinger received this modified virus.
However, he had an intense inflammatory response and developed a dangerous blood-clotting disorder, followed by kidney, liver, and lung failure. Four days after receiving the shot, Gelsinger was declared brain dead.
Gelsinger’s family sued the University of Pennsylvania, which had developed the program.
The tragedy shocked the drug development community, and immediately cooled the research boom in gene therapy. The entire gene therapy industry began to crumble: investors withdrew their funds, startups went bankrupt, the heads of R&D projects were stripped of their titles, and gene therapy centers were shut down.
Gelsinger’s story is well known in the field of gene therapy. The tragedy brought gene therapy development to a near standstill for the next 18 years. Mainly because Gelsinger’s accidental death made many developers believe there were many unknown and uncontrollable serious risk factors in gene therapy, as if shooting in the darkness where the target cannot be seen.
More Deaths Caused by Gene Therapy
Some 18 years after Gelsinger’s death, a gene therapy for an eye illness was approved by the FDA. In 2017, Spark Therapeutics’ Luxturna, a treatment for a rare genetic retinal disease was approved for people who have a mutated RPE65 gene. Luxturna uses a modified virus to deliver a healthy copy of the gene directly to a patient’s retinal cells through eye surgery. It only required local injection, and had little effect on the body. That’s one of the reasons it could succeed on the market. This treatment re-spark interest in the field of gene therapy.
In 2019, the FDA approved Novartis’ Zolgensma® (onasemnogene abeparvovec-xioi), a gene replacement therapy indicated for the treatment of spinal muscular atrophy (SMA) in pediatric patients. Later that year the company got in trouble for not informing the FDA and the European Medicines Agency (EMA) about toxic effects of the intravenous formulation of the drug observed in laboratory animals until seven months later. The company lost an accelerated assessment of the drug by the EMA over the data manipulation issue.
In 2019, in an animal trial of a gene therapy developed by Solid for the treatment of Duchenne muscular dystrophy, three monkeys and three piglets all suffered severe toxicity and eventually died. The company was later placed under a clinical research hold in 2019 after one of its human participants suffered an adverse reaction, though that hold was lifted in 2020.
In 2020, Astellas Pharma acknowledged that a fourth boy died in the troubled Phase I/II trial through which its Astellas Gene Therapies (formerly Audentes Therapeutics) has been evaluating its adeno-associated virus (AAV) gene therapy candidate AT132 in patients with muscular disease, X-linked Myotubular Myopathy (XLMTM). The company had lowered the dose of the treatment after the first three deaths led to an FDA clinical hold on the trial.
What is a Gene?
Genes (DNA) are the most delicate and complex structures in the human body. They exist in the nucleus of the human body’s cells to ensure the normal functioning of the structure and function of the human body; in addition, genes also determine characteristics such as height, gender, appearance, hair color, skin color, blood type, sex, etc.
Scientists have now found that humans have at least about 20,000 to 23,000 genes. If the DNA in the 50 trillion cells of the human body is stretched and connected together, its length is equivalent to 16 times the distance from the earth to the sun. How can such a small nucleus fit such a length? The DNA twists further on top of the double helix, becoming supercoiled, like an old-fashioned telephone wire when twisted.
The outside of DNA is coated with proteins to form chromosomes. There are 23 pairs of chromosomes in each somatic cell of a normal person, and a chromosome contains hundreds to thousands of genes, that is, each chromosome is a highly coiled and compressed shape of genes.
The discovery of DNA is one of the most important and well-known scientific stories of the 20th century. In 1953, American biochemist James Dewey Watson and British physicist Francis Crick published in the journal Nature that they discovered the DNA of two strands of nucleotides, paired as a double helix form, encoding the genetic information of all living things.
Since then, genetic testing technology has flourished, ushering in a new era in biomedicine. For example, the somewhat controversial PCR nucleic acid test we used in the COVID epidemic is a genetic test.
Unfortunately, the gene therapies that have followed have travelled a bumpy road marked by adverse reactions and even death.
Gene Therapy: A Pandora’s Box
The concept of gene therapy is very attractive: the target gene is introduced into the human body to correct an incorrect gene and cure a disease. However, the structure of genes is not as simple as that of proteins. Genes are a very central and important substance in the nucleus. Gene therapies target the problem gene that needs to be corrected but can damage other genes when it is off the target.
The consequence of serious off-targets, several cases of death, is a warning.
The human genetic sequence is very important. It is perhaps the most critical aspect of human physiology. It cannot be changed casually. Genes control all individual organisms, and all important physiological processes such as protein synthesis, cell division, reproduction, etc. Genes can reproduce themselves precisely and faithfully, ensuring the stability of a life’s characteristics.
Modern medicine is still far from able to anticipate the full spectrum of biochemical consequences from pharmaceutical treatments. Acetaminophen was around for over a hundred years before we discovered that pregnant mothers who took the drug were more likely to have children with behavioral issues. That inability to foresee side effects is potentially magnified when it comes to genetic alterations.
The 2020 Nobel Prize in Chemistry has been awarded to two scientists for their contributions to the discovery of a gene editing method called CRISPR-Cas9. This is a technique that allows precise modification of nucleotide fragments and has been described as “God’s scalpel.”
However, this “God’s scalpel” cannot be used casually.
Chinese scientist He Jiankui tried to use gene editing technology to open “Pandora’s Box,” causing an uproar in the scientific community around the world. He Jiankui rashly edited the baby’s genes in the name of helping the offspring of AIDS patients. His unethical and immoral acts got him imprisoned and cost him his career.
As biotechnology advances, there is an every greater need to rational rather than blindly advancing in the name of profits and technological superiority, even if it is done under the guise of medical treatment.
While we all want a better life, we need to be more cautious when it comes to the development of certain technologies that touch the microscopic level of matter in the human body.
We have no idea what could happen as these genetic changes are inherited or how they will interact or interfere with other biological processes.
Who knows what we will discover 100 years from now.
See more here: theepochtimes.com
Header image: Digital Genetics
Please Donate Below To Support Our Ongoing Work To Defend The Scientific Method
PRINCIPIA SCIENTIFIC INTERNATIONAL, legally registered in the UK as a company 
incorporated for charitable purposes. Head Office: 27 Old Gloucester Street, London WC1N 3AX.
Trackback from your site.
Russ D
| #
For those who were STUPID/Conned into taking the Clot Shots……..You’re time is short!
It Doesn’t Work, And Is Now PROVED. Covid-19 vaccines, that is.
https://market-ticker.org/akcs-www?post=245741
Reply
Mark Tapley
| #
Gene therapy treatments were touted as being just around the corner as quick fixes for many of the ap. 5,000 mutations that occur in humans, as well as for other disease. In reality while promising much, just like Nixons highly acclaimed “War on Cancer” it has pretty much been a dismal failure. After over 50 years, cancer is still the second biggest killer after heart disease. Neither of these diseases were a significant cause of mortality in the U.S. until well past the 1900’s. The same is true with the epidemic of type 2 diabetes.
Scientists have found out that when dealing with complex organisms there are lots of unintended consequences that can occur. Germ theory allopathic medicine is based on external drugs, blood toxin vaccines and procedures such as bypasses and stents. Thats where the money (and control ) is. When real health for the vast majority of people is as simple as never being injected with a blood toxin poison, eating a high saturated fat, high protein, low carb diet, with adequate excersice and rest. It is clearly evident from the millions of allopathically duped idiots that lined up for the murder by injection fake virus medical fear campaign that Pasteur’s deception is still going strong.
Reply
Alcheminister
| #
But pharma is not interested in curing disease or addressing causation as that would obsolete and collapse them…so anything pharma is for the purpose of causing more sickness and degeneration…which is also why all pharmaceuticals are unnecessary synthetic toxins peddled based on fraud.
Reply
Russ D
| #
You are so CORRECT!!! As a cancer survivor for 12 years I stay alive be avoiding Doctors and pharmaceuticals.
Plants heal, drugs kill……….ALL drugs!!!
Reply
Alcheminister
| #
Mark, have you seen the delusion associated with supposed vax shedding? When I see people going on about it, it is no wonder they are so easily controlled and why “science” is so dismally shit. The reasoning, the assumptions, jumping to conclusions, reductionist idiocy and religious beliefs makes me think it’s hopeless.
Reply
Mark Tapley
| #
Hello Alcheminister:
The shedding falls in line with the medical con man Ardis and his cobra venom. The trick used here is to have an operative such as Joe Rogan interview a “court expert” such as Dr. Malone and lead their huge audience from the basic fact that there is no virus but only a bunch of fake tests used to induce fear and control. The fake virus medical fear campaign is a powerful tool of the Zionist network to condition the sheep while they are being financially pillaged by their own governments (elite). However it is really just a cover for the long planned implementation of what Klaus (protege of Kissinger). calls the 4th Industrial revolution which is a cover for the U.N. Sustainable Development Initiative Agenda 2030-21. This is actually Marx (Moses Mordecai Levy) original communist manifesto repackaged as technocratic form of Neo feudalism for total control of all aspects of the individuals existence. I link a new video here where Dr.s Cowan, Kaufman and Bailey confront the establishment propaganda of Malone, McCullough and Cole that will never appear on JewTube. It is disappointing that you cannot get Bitchute (a British network) but you know what is going on. Perhaps others may be reached with the truth.
https://www.bitchute.com/video/DpopiPTekMPg/
Reply
Russ D
| #
Then prove that the virus exist. The entire PLANdemic was based on positive tests from the fraudulent PCR test. The PCR test is a LIE……PERIOD!
THERE IS NO EVIDENCE of the EXISTENCE for ANY VIRUS ISOLATED by ANYONE ANYWHERE in the WORLD!
https://www.drrobertyoung.com/post/there-is-no-evidence-of-the-existence-for-any-virus-isolated-by-anyone-anywhere-in-the-world-part-2?utm_campaign=51ae368e-bb51-4316-b85a-d4856dcec492&utm_source=so&utm_medium=mail&cid=3f9e272e-9236-4d52-ba74-f2b656b7b05a
Reply
Alcheminister
| #
That’s the point, some like Lanka, Kaufman, Cowan, Bailey address the fundamentals of the fraud. It’s the only way out of the BS (and similar attempted BS in the future), addressing the fraud of “virus” functionality, supposed contagion and pasteur methodology.
Other popularized “truthers” (such as those mentioned) refuse to address that, because of investment, incentivization, propping up and perpetuating the enabling fundamentals of the fraud, peddling toxic shit. I mean, the average person apparently doesn’t even understand that protocol is inherently sub-optimal, homogenizing failure shit.
I’ve confronted a bunch of those “truthers” and (likely associated) commenters questions, stated some things…I don’t get refutations hey.
Alcheminister
| #
Yeah I’ve been bitching about Vanden Bossche, McCullough, Malone, Cole, Kory, Nass, Kirsch, Zelenko, Lyons-Weiler, etc. from the moment I noticed their BS.
But bitchute videos don’t work here.
Reply
Alcheminister
| #
Regarding the “snake venom”, I don’t think it’s entirely impossible that synthetic analogs of some snake venom proteins, peptides or whatever are associated with vaccines. But I wouldn’t really know.
Reply
Mark Tapley
| #
Hello Alcheminister:
In the link below biologist Mile Donio takes all the purported data put forth by Ardis and even goes through the chemical diagrams used in the snake venom hoax showing it is just more misinformation used to distract from the fact that viruses do not exist and to maintain anxiety in the sheep so they are more susceptible to elite control. The same syndicate of course are behind the “climate change” CO2 scam and the current fake war in Ukraine. I link another video on “The Ghost of Kiev” baloney also:
https://www.bitchute.com/video/Db58r9ccOpib/
https://www.bitchute.com/video/1tQjqeWJXHY/
givasi2339
| #
I basically make about $6,000-$8,000 a month online. It’s enough to comfortably replace my old jobs income, especially considering I only work about 10-13 hours a week from home. I was amazed how easy it was after I tried it….
HERE ➤➤ https://www.workbz.com
Reply