Fights COVID Like Hydroxychloroquine, yet Easier to Find
The Substack Modern Discontent recently posted an anthology series on the benefits of quercetin, including the finding that it works like hydroxychloroquine, a drug found to be effective against SARS-CoV-2 when used early enough.
Part 1 begins with a brief overview of what quercetin is and its basic mechanisms of action. Quercetin is a flavonoid found in a variety of fruits and vegetables, such as onions and shallots, apples, broccoli, asparagus, green peppers, tomatoes, red leaf lettuce, strawberries, raspberries, blueberries, cranberries, black currants and green tea.
The quercetin content in any given food is largely dependent on light exposure, though, so depending on the country you’re in, different foods will top the list of most quercetin-rich.
Quercetin Against SARS-CoV-2
In Part 2 of the anthology, Modern Discontent reviews the evidence behind the recommendation to use quercetin against COVID-19 specifically. As mentioned, zinc has antiviral activity, and quercetin helps shuttle the zinc into the cell. But quercetin also has other mechanisms of action that make it useful in the fight against COVID-19.
For example, quercetin has been shown to:
- Inhibit SARS-CoV-2 spike protein to ACE2 receptor docking. Computational modeling studies have shown quercetin can bind to the ACE2 receptor and the spike protein interface, thereby inhibiting the two from binding together. By preventing viral attachment, it helps prevent viral entry into the cell. Commenting on one of these studies, Modern Discontent notes:
“Although [a] computer modeled study, the evidence here suggests that quercetin’s binding activity to ACE2 is comparable to other standard of care drugs used to treat SARS-CoV-2 (eg. Remdesivir, Lopinavir, Ritonavir).”
- Inhibit lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNF-α) production in macrophages. (TNF-α is a cytokine involved in systemic inflammation, secreted by activated macrophages, a type of immune cell that digests foreign substances, microbes and other harmful or damaged components.)
- Inhibit the release of proinflammatory cytokines and histamine by modulating calcium influx into the cell.
- Stabilize mast cells and regulate the basic functional properties of immune cells, thereby allowing it to inhibit “a huge panoply of molecular targets in the micromolar concentration range, either by down-regulating or suppressing many inflammatory pathways and functions.”
- Act as a zinc ionophore, i.e., a compound that shuttles zinc into your cells. This is one of the mechanisms that can account for the effectiveness seen with hydroxychloroquine, which is also a zinc ionophore.
- Boost interferon response to viruses, including SARS-CoV-2, by inhibiting the expression of casein kinase II (CK2) — CK2 is an enzyme that is fundamental to controlling homeostasis at the cellular level. There is evidence that it down-regulates the ability a cell has to generate Type 1 interferon when attacked by a virus. However, the interferon does not function by attacking the virus. Instead, it tells the infected cell and the cells that surround the infected cell to make proteins that stop viral replication. In a nutshell, quercetin stops CK2 from interfering with the action of Type 1 interferon so cells receive the signal to stop viral replication.
- Modulate NLRP3 inflammasome, an immune system component involved in the uncontrolled release of proinflammatory cytokines that occurs during a cytokine storm.
- Exert a direct antiviral activity against SARS-CoV — Quercetin’s general antiviral capacity has been attributed to three primary mechanisms of action:
- Binding to the spike protein, thereby inhibiting its ability to infect host cells
- Inhibiting replication of already infected cells
- Reducing infected cells’ resistance to treatment with antiviral medication
- Inhibit the SARS-CoV-2 main protease.
Quercetin in COVID-19 Medical Literature
In Part 3, Modern Discontent reviews some of the clinical trials that have taken place. One COVID-19-specific study found that people who took zinc and two zinc ionophores — quinine drops and quercetin — had lower incidence of COVID-19 than the control group. Over the course of the study (20 weeks), only two of the 53 test subjects became symptomatic, compared to 12 of the 60 controls. As noted by Modern Discontent:
“Although this didn’t test quercetin in isolation, the study does suggest that over-the-counter, easily accessible compounds may be extremely beneficial in fighting against COVID, especially when taken as a prophylactic.”
In another trial, 76 outpatients who tested positive but had only mild symptoms were given 1,000 mg of Quercetin Phytosome® (quercetin in sunflower phospholipids that increase oral absorption 20-fold) per day for 30 days, in addition to standard care (analgesics, oral steroids and antibiotics). Another 76 patients were given standard of care only.
In the quercetin group, only 9.2 percent of participants went on to require hospitalization, compared to 28.9 percent of patients who received standard of care only. According to the authors:
“The results revealed a reduction in frequency and length of hospitalization, in need of non-invasive oxygen therapy, in progression to intensive care units and in number of deaths.
The results also confirmed the very high safety profile of quercetin and suggested possible anti-fatigue and pro-appetite properties. QP [Quercetin Phytosome®] is a safe agent and in combination with standard care, when used in early stage of viral infection, could aid in improving the early symptoms and help in preventing the severity of COVID-19 disease.”
Quercetin was also featured in two scientific reviews published in 2020. The first, published in in the Integrative Medicine journal in May 2020,32 highlighted quercetin’s promotion of SIRT2, which inhibits NLRP3 inflammasome.
The second review article, published in the June 19, 2020, issue of Frontiers in Immunology, highlighted quercetin’s usefulness as a COVID-19 treatment when used in conjunction with vitamin C. The vitamin C recycles oxidized quercetin, producing a synergistic effect. It also enhances quercetin’s antiviral capacity.
Food as Medicine
With the advent of processed foods, many important nutrients have been lost or minimized in the average person’s diet. Quercetin, being found in fresh fruits, vegetables and berries is one of them. Unfortunately, while essential vitamins and minerals are generally recognized for their importance, antioxidants such as quercetin are often overlooked, and sometimes labeled as “pseudoscience” or “fad” supplements. As noted by Modern Discontent:
“The great number of benefits that these compounds contribute to humans cannot be overstated … An argument can be made that not only could quercetin prove beneficial to our health, but an absence of it may prove detrimental in the long term.”
If COVID-19 has taught us anything, it’s the importance of basic health and a healthy immune function. In this regard, a diet high in fresh fruits and vegetables can go a long way. Nutritional supplements also have their place, especially in situations like a pandemic.
Summary
In conclusion, Modern Discontent provides the following summary of findings:
• “There’s evidence that quercetin may work similarly to hydroxychloroquine — It seems that quercetin may operate as both an immunomodulator and a zinc ionophore. Its use as an over-the-counter anti-allergic supplement as well as its use for asthma indicates an ability to affect the production of histamine and cytokines
• Quercetin has plenty of other benefits — … Antioxidants … are some of the most well studied compounds, with possible anti-cancer, pro-heart and pro-organ benefits. Add on possible antimicrobial properties and it becomes hard to argue that this is nothing more than a possible fad supplement.
• Although limited, there is some evidence that quercetin may be effective against SARS-CoV2 — Computer models and in vitro studies suggest that ACE2 receptors and the main protease of SARS-CoV2 may be good target candidates for quercetin … the limited number of studies suggest quercetin may be effective, especially if used early on or as a prophylactic.
• Dietary quercetin is the main source of quercetin, and its deficiency in modern diets may be contributing to our health problems — Quercetin is primarily sourced from colorful fruits, vegetables, teas … all foods that many of our ancestors would have consumed on a regular basis … Modern ‘enriched’ foods tend to supplement with additional vitamins and minerals, but may miss out on other plant-derived compounds that have played a substantial role in our diet.
Similar to reduced sunlight exposure and the need for increased vitamin D supplementation, we may need to look at possible supplementation of overlooked compounds such as polyphenols. Sourcing these compounds from real foods would prove the most beneficial, but in groups of people who may not have access to fresh fruits and vegetables, quercetin and polyphenol supplementation may be useful.
This would include people with alternative diets such as keto, who may avoid high carb fruits, and thus may be missing a key nutrient in their diets.
Quercetin has plenty of benefits, and for those who may be missing out on it in their diet they may want to look into sourcing it with supplementation. Don’t take this as a prescription or recommendation, but an argument to examine your own health and see what you may be lacking …”
See more here: theepochtimes.com
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Alcheminister
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This is the problem…
“…standard care (analgesics, oral steroids and antibiotics). Another 76 patients were given standard of care only.”
So on one hand, you have some potentially beneficial elements that are somewhat natural. Sunflowers, turmeric, whatever.
Then, you kinda ruin that with synthetic analgesics, steroids, antibiotics shitty hospital food, in hospitals that are incredibly toxic, have damaging diagnostics in various forms, etc…that is in a sense, used to avoid addressing those fundamentals (that of personal health status, masking the damage of the pharmaceuticals with some naturally beneficial properties, that perhaps even have essential elements.
So where are the studies of say, a few natural factors (say, not using pharmaceuticals, getting sunlight, partying on the beach, drinking a few beers, using some other recreational substances, which are NOT synthetic vs maybe, HCQ, IVM, AZM, vaccines, whatever pharma.
Oh and anyone trying to suggest sars-cov2 is a thing is talking shit.
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Heretic Jones
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COVID??? Hilarious.
Fake and gay.
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Alcheminister
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No dude. You can’t say it’s gay these days. Belief in covid is faggot shit.
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Charles Higley
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We have to stop mentioning Covid-19. As it was and has never been isolated and shown to cause the purported wide and varied symptoms and the PCR test is so nonspecific that it detects any coronavirus, including colds and flus, Covid-19 is simply the new name for ALL COLD and FLU viruses. And, for that matter, anything that is effective against the mythical Covid-19 by definition is effective against colds and flus, since that is what Covid-19 is. Whatever the virus was that went through a couple of years ago, it was, overall, less lethal than a normal flu season, except for the lethal use of ventilators, lethal use of remdesivir, negligent and illegal medical practices (not using antibiotics on lung involvements), and the isolation and abuse of the elderly.
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Richard Noakes
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All of the above “treatments” are for your body, but nothing is considered for your head, where the trouble starts from. Let me simplify that. You cannot catch Covid that is an impossibility – you catch a Coronavirus which is in the air we breathe coughed, sneezed or expelled there from an infected person and a Coronavirus spore is 1/1000th the size of a grain of rice and after it gets into your warm, wet, nasal passages, it seeds itself there and after 7 to 14 days of self isolation (funny that) it becomes Covid – or Pneumonia – in your head – hence Long Covid – and in your lungs as Pneumonia.
There is only one free easy way to defeat Coronavirus and that is to kill it as quickly as possible, after you think you might have an infection: 3 minutes from preparation to job done!!
Everything else you have read, or heard, is totally irrelevant – how simple is that?
Covid Crusher: Mix one heaped teaspoon of Iodine table salt in a mug of warm clean water, cup a hand and sniff or snort the entire mugful up your nose, spitting out anything which comes down into your mouth. If sore, then you have a virus, so continue morning noon and night, or more often if you want, until the soreness goes away (2-3 minutes) then blow out your nose and flush away, washing your hands afterwards, until when you do my simple cure, you don’t have any soreness at all, when you flush – job done. Also swallow a couple of mouthfuls of salt water and if you have burning in your lungs, salt killing virus and pneumonia, there too.
My simple salt water cure, kills all Coronaviruses and viruses, as soon as you think you have an infection, or while self isolating, before the viruses mutate into the disease in your head and body, for which there is no cure – that is, after you have been out shopping, or mixing with people with potentially, Omicron or Delta viruses, or any other virus.
It washes behind the eyes, the brain bulb, brain stem (Long Covid), The Escutcheon Tubes to the inner ears and the top of the throat which is at a point roughly level with half way up your ears and not where your mouth is and down the back of your throat, when sore.
I have been doing this simple cure for over 28.5 years and I am and others, never sick from viruses and there is no reason why any of you should be either – when your only alternative are those vaccines!!
I do my simple preparation, after I have been out and about, or come into contact with people who have been vaccinated – it has kept me safe – and I hope it keeps me safe for the foreseeable future as Graphene Oxide is in the very air we breathe, outside, as well, but now from the vaccinated!!
Simply put, if the inside of your nose is dry and crusty, you are OK, if your nose is runny, you really need to do a salt water sniffle as quickly as possible and monitor the results, to see if further salt water sniffles are necessary, but later on in that evening – so far – I remain immune from potential Covid infections, doing just this.
No vaccines for me – ever – note: I have been doing this simple cure for over 28.5 years, so I know what I am talking about.
Richard
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Alcheminister
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“All of the above “treatments” are for your body, but nothing is considered for your head, where the trouble starts from.”
So true, because if you believe in sars-cov2, contagion or supposed virus functionality you have NOT been paying attention or learned anything and are an indoctrinated cultist susceptible to propagandist media projections for purposes of control and exploitation. That is indeed a very serious illness, having such weak defense against hypnotism and religious beliefs.
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Alcheminister
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Richard, did you know RTIs often result from toxicity and deficiency factors? I vitamin ACED my “tests”.
For instance, children in certain parts of Africa…sometimes have pneumonia (which they labeled as measles because of the initial symptomatic results of rash or whatever). Though, it is also known that vitamin A deficiency is fairly common in those areas/populations where that is prevalent. So then those children with already severe illness are given two doses (that’s right, only two doses) of vitamin A and their “measles”/pneumonia magically vanishes and mortality drops by 80%…what’s that mean?
Here’s a reference that seemingly almost begrudgingly mentions that:
https://pubmed.ncbi.nlm.nih.gov/11869601/
So, do you think salt water can be a substitute for that severe systemic vitamin A deficiency?
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Alcheminister
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Sorry…
So, do you think salt water can be a substitute for addressing that severe systemic vitamin A deficiency?
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Photios
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“…continue morning noon and night…until the soreness goes away (2-3 minutes)”
🙂
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Alcheminister
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LOL. I didn’t even read that.
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