Dissolution of Spike Protein by Nattokinase
Far and away the most common question I get from those who took one of the COVID-19 vaccines is: “how do I get this out of my body.”
The mRNA and adenoviral DNA products were rolled out with no idea on how or when the body would ever breakdown the genetic code.
The synthetic mRNA carried on lipid nanoparticles appears to be resistant to breakdown by human ribonucleases by design so the product would be long-lasting and produce the protein product of interest for a considerable time period.
This would be an advantage for a normal human protein being replaced in a rare genetic deficiency state (e.g. alpha galactosidase in Fabry’s disease). However, it is a big problem when the protein is the pathogenic SARS-CoV-2 Spike. The adenoviral DNA (Janssen) should broken down by deoxyribonuclease, however this has not be exhaustively studied.
This leaves dissolution of Spike protein as a therapeutic goal for the vaccine injured. With the respiratory infection, Spike is processed and activated by cellular proteases including transmembrane serine protein 2 (TMPRSS2), cathepsin, and furin.
With vaccination, these systems may be avoided by systemic administration and production of Spike protein within cells. As a result, the pathogenesis of vaccine injury syndromes is believed to be driven by accumulation of Spike protein in cells, tissues, and organs.
Nattokinase is an enzyme is produced by fermenting soybeans with bacteria Bacillus subtilis var. natto and has been available as an oral supplement. It degrades fibrinogen, factor VII, cytokines, and factor VIII and has been studied for its cardiovascular benefits.
Out of all the available therapies I have used in my practice and among all the proposed detoxification agents, I believe nattokinase and related peptides hold the greatest promise for patients at this time.
Tanikawa et al examined the effect of nattokinase on the Spike protein of SARS-CoV-2. In the first experiment they demonstrated that Spike was degraded in a time and dose dependent manner in a cell lysate preparation that could be analogous to a vaccine recipient.
The second experiment demonstrated that nattokinase degraded the Spike protein in SARS-CoV-2 infected cells. This reproduced a similar study done by Oba and colleagues in 2021.
See link here: substackcdn.com
Nattokinase is dosed in fibrinolytic units (FU) per gram and can vary according to purity. Kurosawa and colleagues have shown in humans that after a single oral dose of 2000 FU D-dimer concentrations at 6, and 8 hours, and blood fibrin/fibrinogen degradation products at 4 hours after administration elevated significantly (p < 0.05, respectively).
Thus an empiric starting dose could be 2000 FU twice a day. Full pharmacokinetic and pharmacodynamic studies have not been completed, but several years of market use as an over-the-counter supplement suggests nattokinase is safe with the main caveat being excessive bleeding and cautions with concurrent antiplatelet and anticoagulant drugs.
Based on these findings, nattokinase and similar products such as serrapeptase should undergo well-funded, accelerated preclinical and clinical development programs. The issue at hand is the urgency of time, similar to that with SARS-CoV-2 infection and empiric early therapy.
It will take up to 20 years to have a fully developed pharmaceutical profile to characterize the safety and efficacy of nattokinase in the treatment of vaccine injury and post-COVID syndromes. Large number of people are sick now and many believe empiric treatment is justified given sufficiently low risk of side effects and potentially high reward.
My recommendation is to discuss this with your doctor or seek a specialist in holistic or naturopathic medicine who is experienced with the safety profile of nattokinase in a range of applications.
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About the author: Dr Peter McCullough is an internist, cardiologist, epidemiologist, and the Chief Scientific Officer of The Wellness Company. Since the outset of the pandemic, Dr. McCullough has dozens of peer-reviewed publications on the infection and has commented extensively on the medical response to the COVID-19 crisis.
Dr. McCullough is one of the most published cardiologist ever in America, with over 1,000 publications and 660 citations in the National Library of Medicine and is a recipient of the Simon Dack Award from the American College of Cardiology and the International Vicenza Award in Critical Care Nephrology for his scholarship and research.
More at petermcculloughmd.substack.com
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Saeed Qureshi
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@ “The second experiment demonstrated that nattokinase degraded the Spike protein in SARS-CoV-2 infected cells.”
Keep this thought when reading that no one has a specimen of the actual SAR-COV-2 virus, its infected cells, or Spike protein. So how such studies/testing could have been done? “Science”!
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SparkyZ
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“As a result, the pathogenesis of vaccine injury syndromes is believed to be driven by accumulation of Spike protein in cells, tissues, and organs.”
“Nattokinase is an enzyme is produced by fermenting soybeans . . . I believe nattokinase and related peptides hold the greatest promise for patients at this time.
So how is this supposed to get inside the cells, tissues and organs? Taken orally it would be degraded. Injected, it would not get inside the cell. What is your theory on the mechanism?
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Leonard Winokur
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Have you read the three papers cited at the end of this article? It is reasonable to expect that the theory and methodological rationales will be explained therein; if you notice any anomalies or shortcomings in these papers, then it would be more useful to take these up with the papers’ authors (most scientific papers provide correspondence addresses for at least the respective main author). Please bear in mind that Dr McCullough’s above piece is a review, and which will be why he has given his sources at the end.
Other points to bear in mind. Absence of proof does not equate to proof of absence. Failure to have isolated any designated virus from its host cell(s) does not mean it does not exist; type ‘virus’ or ‘phage’ into a Google Scholar advanced search along with any of the search terms ‘isolation’, ‘observation’, or ‘characterisation’ and it will return several examples with electron micrographs of host cells along with the infective agent (or with what look like, and could reasonably assumed on deductive grounds, to be the infecting agent).
Have you ever published a peer-reviewed paper, or conducted research, in whatever field of scientific endeavour? Beware your susceptibility to the Dunning-Kruger effect.
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JaKo
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Dear Leo,
While agreeing with your logical inference that absence of proof is not identical to proof of absence, I would strongly advise you to avoid denigrating people here you may know nothing about.
Further, I would recommend to all a very interesting article about the “treatment” some scientists have been exposed to when neither following nor parroting the established dogma:
Dr. R R Rife
especially, as in that case, disagreeing with the monsters behind pharmageddon…
Cheers, JaKo
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Saeed Qureshi
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Thanks, Jako; your comment says it all.
I do not think that I need to add anything further, except people still have a strong belief in the “official” narrative and think that the (medical) journals entertain “unofficial” comments and narratives.
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MattH
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Hi JaKo. Fascinating article on Dr Rife, thank you.
The specific resonant frequencies to destroy specific viruses and bacterium could explain why people look quite ill when I start singing. 🙂
It also explains how water divination works. (dowsing)
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Mofflington Head
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Dunning-Kruger effect, in psychology, a cognitive bias whereby people with limited knowledge or competence in a given intellectual or social domain greatly overestimate their own knowledge or competence in that domain relative to objective criteria or to the performance of their peers or of people in general.
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SparkyZ
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“Have you read the three papers cited at the end of this article?”
I had not, but have now. They do not address this issue at all. Extracts treated in vitro do not provide any guidance on administration.
“Have you ever published a peer-reviewed paper, or conducted research, in whatever field of scientific endeavour? Beware your susceptibility to the Dunning-Kruger effect.”
Yes. I have. Multiple papers and have a Ph.D. in Molecular and Cell Biology from one of the top programs in the world. I held Postdoctoral and Faculty positions as well. You should take JaKo’s advice.
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Antonio
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Basta leggere il documento del dr. Drosten e Corman riferito al tampone PCR in assenza di isolati virus abbiamo nella GenBank europea cioè in silico le sequenze della vecchia sars. Ma non era un nuovo virus? Fuffa…..
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Moffin
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Could somebody please translate Antonio’s comment. I think I understand Fuffa; fluff; without substance.
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Jerry Krause
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Hi Moffin,
Could you give me an on the scene report about the typhoon of the century which I read about hitting NZ?
Have a good day
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Moffin
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Hi Jerry. We call them Tropical Cyclones. By the time the storm reached New Zealand it had lost some energy as the water temperature at Northland is about 22degrees C.
https://www.ventusky.com/?p=1;102;1&l=temperature-water
(move your computer mouse around the global chart and see water temp just east of New Guinea is 31 degrees.)
The center of the depression traversed south just off the East coast so the Eastern coastal areas received the extreme wind and rain. There was similar flooding in 1938 and cyclone Bola in 1988 had more rainfall in some areas but this storm (Gabrielle) the rain was more widespread and consistent.
The most devastated areas are Gisborne and Hawkes Bay. After Bola in 1988 there was a forestry planting regime implemented (pinus radiata) which is now being harvested. The slash (trimmings) and small logs washed down stream by the flash floods accumulated at bridges so many bridges have been washed out by this forestry waste. The government today announced an enquiry into the forestry waste destroying infrastructure. The forestry waste used to be burned off but the greenies stopped this management.
With the logs blocking the rivers at the bridges, major rivers broke their banks and the rivers joined to form a major lake on the vast coastal flood plains, which are the country’s major fruit and vege growing areas. Time to plant home gardens.
The inland mountains and hill country farms are very steep so there was inadequate warnings of the impending disaster although weather forecasts were very accurate days in advance.
People were rescued off rooves. Some climbed into the ceiling of their house and smashed a hole in the roof to escape. Some could not escape the roof cavity and drowned there.
There are about 11 confirmed deaths but a chopper pilot saw human bodies caught up in trees and there is over 100 people still unaccounted for.
Heaps of orchards have been washed out by the torrents or smothered by one to one and a half metres of silt, which will kill the trees.
When you have days of warnings that a tropical cyclone is coming you don’t pretend that mother nature is not to be taken seriously.
That reference I have posted can show wind patterns at different altitudes. (jetstreams)
Jerry Krause
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Hi PSI Readers and Moffin,
We can believe this detailed report because this fisherman has gained his knowledge of natural storms etc. because of his lifetime experiences as a fisherman and he reads as well as observes weather and tides.
Great summary of what occurred and why. But I question how many of PSI readers will ever read it.
Have a good day
Jerry Krause
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Hi Moffin,
When I submitted my previous comment, I had not yet looked at your link.
Right now in Salem OR and north to Portland and Seattle we are experiencing very non-normal weather at this time of year with several inches of snow on the ground and ice under it at an air temperature of 31F at my home and maybe colder at the airport which is about 400 feet lower. Therein is the problem: elevation differences when roads are snowy and icy.
And weather forecasters were saying, at length, last night what had occurred then was not predicted. Why? The weather models being used to predict weather do not consider localized terrains like the Colombia River and its gorge.
One more fact. I have repeated quoted the meteorologist R.C. Sutcliffe who in 1966 wrote that clouds have a great influence upon CLIMATE, hence weather as climate is merely the average of local weather.
Thank you very much for calling this link to our attentions. Which observed information did not yet exist in 1966.
Have a good day
Jerry Krause
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Hi Moffin,
At (https://principia-scientific.com/?s=The+Federal+Government+is+Tracking)
I suspect you know but in case you don’t, I have started a series of brief comments at this link and I plan to comment there about the link you have sent me.
Have a good day
Moffin
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Hi Jerry and curious bystanders.
The death toll of the New Zealand ex-tropical cyclone now stands at 11 dead and 10 missing that police have ‘extreme concern’ for.
chris
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sorry, but did you ever work in a biochemistry lab where you can GENETICALLY EXPRESS ANY PROTEIN out there??? If you have the gene, you can do anything!!! For this no virus is needed….
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SparkyZ
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“sorry, but did you ever work in a biochemistry lab where you can GENETICALLY EXPRESS ANY PROTEIN out there??? If you have the gene, you can do anything!!! For this no virus is needed….”
Not sure if this is directed at me… but yes. Many many times.
But while you are correct, getting the nattokinase to where it needs to be is much more difficult than simply expressing it in E. coli, yeast or any other organism. One could introduce it via the mRNA “vaccine” approach, but I see that as problematic.
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Jakie
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It’s not science…
It’s $cientism. The NWO Religion
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Frank S.
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Since many who succumbed to the psy-op and took the jab , may not have years for therapies to be proven by long-term study, available naturopathic products with long safety records are worth administering. I’ve heard Ivermectin, HCQ, zinc and NAC also help debilitate the evil Spikes
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chris
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Here a official MEROPS data base result:
‘Spike glycoprotein’
Hits returned = 23
Cleavage Site Peptidase
peptide-Ala688+Ser-peptide S01.131: elastase-2
peptide-Val663+Ser-peptide S01.131: elastase-2
peptide-Val687+Ala-peptide S01.131: elastase-2
peptide-Leu666+Arg-peptide S01.133: cathepsin G
peptide-Ala688+Ser-peptide S01.134: myeloblastin
peptide-Val663+Ser-peptide S01.134: myeloblastin
peptide-Val687+Ala-peptide S01.134: myeloblastin
peptide-Arg667+Ser-peptide S01.151: trypsin 1
peptide-Arg682+Arg-peptide S01.151: trypsin 1
peptide-Arg683+Ala-peptide S01.151: trypsin 1
peptide-Arg685+Ser-peptide S01.151: trypsin 1
peptide-Arg797+Ser-peptide S01.247: epitheliasin
peptide-Arg815+Ser-peptide S01.247: epitheliasin
peptide-Arg887+Ser-peptide S01.247: epitheliasin
Peptide-Arg537+Ser-Peptide S08.071: furin
peptide-Arg667+Ser-peptide S08.071: furin
peptide-Arg685+Ser-peptide S08.071: furin
peptide-Arg751+Ser-peptide S08.071: furin
Peptide-Arg537+Ser-Peptide S08.073: PCSK2 peptidase
Peptide-Arg537+Ser-Peptide S08.074: PCSK4 peptidase
Peptide-Arg537+Ser-Peptide S08.075: PCSK6 peptidase
Peptide-Arg537+Ser-Peptide S08.076: PCSK5 peptidase
Peptide-Arg537+Ser-Peptide S08.077: PCSK7 peptidase
That result is VERY INCOMPLETE!!! The dipeptide Pro-Pro is NOT easy digestible, yet that data system is not indicating the DPPIV peptidase, which would cut this bond! Another important ‘diluter’. IN general I’d say the more proteases the better!
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Cathleen
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It’s been demonstrated to improve blood circulation and and helps decrease the risk of a variety of cardiovascular diseases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372539/
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VOWG
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It seems to work as a blood thinner.
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