COVID TEST FAIL: External Peer Review Exposes 10 Key Scientific Flaws
Policymakers worldwide have been relying on a junk science test for COVID-19. That’s according to a team of eminent international experts. A study relied on since January 2020 as ‘proof’ that a PCR test can reliably diagnose the novel coronavirus has been firmly debunked in a compelling new open letter.
The bombshell dropped on November 27th 2020 when an independent international consortium of life-science experts published their detailed open letter exposing ten critical errors in the study “Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR” published in Eurosurveillance (January 23rd, 2020).
The World Health Organization (WHO) COVID19 testing protocol, among others, is directly derived from the now discredited study.
The paper (hereafter referred to as Corman-Drosten paper), published by the journal, Eurosurveillance appeared early in 2020 describing what it claims to be a reliable RT-PCR method to detect the novel Coronavirus (also known as SARS-CoV2).
The paper (and/or its WHO variant) has been systematically relied upon by governments worldwide to justify the tens of millions of swab tests which, we were told, would reliably determine who has been infected by COVID19.
There is just one problem. It is demonstrably shown to be junk science.
According to the consortium open letter (read here) the paper is:
“severely flawed….External peer review of the RTPCR test to detect SARS-CoV2 reveals 10 major scientific flaws at the molecular and methodological level: consequences for false positive results.”
The consortium say they made previous attempts to try to persuade the journal to retract the flawed paper but were ignored so they resorted to publishing their findings in this open letter instead. The fact the journal steadfastly ignored all prior attempts to have the paper retracted may reasonably be inferred as collusion to perpetuate the Big COVID19 Lie.
We have now reached the end days for any compelling scientific basis that we have been living through a validated global pandemic. Any ‘pandemic’ worthy of that name is merely a pandemic of false positives from a junk test.
Let no one be in any doubt – due to the insanity of draconian lockdown measures – any further reliance on this test for public policy purposes would be criminal in the wake of the real devastation wrought on national economies and the health and wellbeing of citizens.
As we edge closer to the end of 2020 we can look back on a year of not especially high excess mortality rates globally. Statisticians are increasingly of the view that there is no compelling evidence to validate a ‘deadly’ novel coronavirus pandemic and this esteemed consortium of scientists have put their finger fairly and squarely on the root of the problem – junk science and group think.
The damning new letter explains the science as follows:
“In light of all the consequences resulting from this very publication for societies worldwide, a group of independent researchers performed a point-by-point review of the aforesaid publication in which
1) all components of the presented test design were cross checked,
2) the RT-qPCR protocol-recommendations were assesses w.r.t. good laboratory practice, and
3) parameters examined against relevant scientific literature covering the field.
The published RT-qPCR protocol for detection and diagnostics of 2019-nCoV and the manuscript suffer from numerous technical and scientific errors, including insufficient primer design, a problematic and insufficient RT-qPCR protocol, and the absence of an accurate test validation. Neither the presented test nor the manuscript itself fulfils the requirements for an acceptable scientific publication. Further, serious conflicts of interest of the authors are not mentioned. Finally, the very short timescale between submission and acceptance of the publication (24 hours) signifies that a systematic peer review process was either not performed here, or of problematic poor quality. We provide compelling evidence of several scientific inadequacies, errors and flaws.”
SUMMARY CATALOG OF ERRORS FOUND IN THE PAPER
The Corman-Drosten paper contains the following specific errors:
1. There exists no specified reason to use these extremely high concentrations of primers in this protocol. The described concentrations lead to increased nonspecific bindings and PCR product amplifications, making the test unsuitable as a specific diagnostic tool to identify the SARS-CoV-2 virus.
2. Six unspecified wobbly positions will introduce an enormous variability in the real world laboratory implementations of this test; the confusing nonspecific description in the Corman-Drosten paper is not suitable as a Standard Operational Protocol making the test unsuitable as a specific diagnostic tool to identify the SARS-CoV-2 virus.
3. The test cannot discriminate between the whole virus and viral fragments. Therefore, the test cannot be used as a diagnostic for intact (infectious) viruses, making the test unsuitable as a specific diagnostic tool to identify the SARS-CoV-2 virus and make inferences about the presence of an infection.
4. A difference of 10° C with respect to the annealing temperature Tm for primer pair1 (RdRp_SARSr_F and RdRp_SARSr_R) also makes the test unsuitable as a specific diagnostic tool to identify the SARS-CoV-2 virus.
5. A severe error is the omission of a Ct value at which a sample is considered positive and negative. This Ct value is also not found in follow-up submissions making the test unsuitable as a specific diagnostic tool to identify the SARS-CoV-2 virus.
6. The PCR products have not been validated at the molecular level. This fact makes the protocol useless as a specific diagnostic tool to identify the SARS-CoV-2 virus.
7. The PCR test contains neither a unique positive control to evaluate its specificity for SARS-CoV-2 nor a negative control to exclude the presence of other coronaviruses, making the test unsuitable as a specific diagnostic tool to identify the SARS-CoV-2 virus.
8. The test design in the Corman-Drosten paper is so vague and flawed that one can go in dozens of different directions; nothing is standardized and there is no SOP. This highly questions the scientific validity of the test and makes it unsuitable as a specific diagnostic tool to identify the SARS-CoV-2 virus.
9. Most likely, the Corman-Drosten paper was not peer-reviewed making the test unsuitable as a specific diagnostic tool to identify the SARS-CoV-2 virus.
10. We find severe conflicts of interest for at least four authors, in addition to the fact that two of the authors of the Corman-Drosten paper (Christian Drosten and Chantal Reusken) are members of the editorial board of Eurosurveillance. A conflict of interest was added on July 29 2020 (Olfert Landt is CEO of TIB-Molbiol; Marco Kaiser is senior researcher at GenExpress and serves as scientific advisor for TIB-Molbiol), that was not declared in the original version (and still is missing in the PubMed version); TIB-Molbiol is the company which was “the first” to produce PCR kits (Light Mix) based on the protocol published in the Corman-Drosten manuscript, and according to their own words, they distributed these PCR-test kits before the publication was even submitted [20]; further, Victor Corman & Christian Drosten failed to mention their second affiliation: the commercial test laboratory “Labor Berlin”. Both are responsible for the virus diagnostics there [21] and the company operates in the realm of real time PCR-testing.
Signing the letter are a ‘who’s who’ of eminent life scientists including:
Dr. Pieter Borger (MSc, PhD), Molecular Genetics, W+W Research Associate, Lörrach, Germany
Prof. Dr. Ulrike Kämmerer, specialist in Virology / Immunology / Human Biology / Cell Biology, University Hospital Würzburg, Germany
Prof. Dr. Klaus Steger, Department of Urology, Pediatric Urology and Andrology, Molecular Andrology, Biomedical Research Center of the Justus Liebig University, Giessen, Germany
Prof. Dr. Makoto Ohashi, Professor emeritus, PhD in Microbiology and Immunology, Tokushima University, Japan
Prof. Dr. med. Henrik Ullrich, specialist Diagnostic Radiology, Chief Medical Doctor at the Center for Radiology of Collm Oschatz-Hospital, Germany
Rajesh K. Malhotra (Artist Alias: Bobby Rajesh Malhotra), Former 3D Artist / Scientific Visualizations at CeMM – Center for Molecular Medicine of the Austrian Academy of Sciences (2019-2020), University for Applied Arts – Department for Digital Arts Vienna, Austria
Dr. Michael Yeadon BSs(Hons) Biochem Tox U Surrey, PhD Pharmacology U Surrey. Managing Director, Yeadon Consulting Ltd, former Pfizer Chief Scientist, United Kingdom
Dr. Kevin P. Corbett, MSc Nursing (Kings College London) PhD (London South Bank) Social Sciences (Science & Technology Studies) London, England, UK
Dr. Clare Craig MA, (Cantab) BM, BCh (Oxon), FRCPath, United Kingdom
Kevin McKernan, BS Emory University, Chief Scientific Officer, founder Medical Genomics, engineered the sequencing pipeline at WIBR/MIT for the Human Genome Project, Invented and developed the SOLiD sequencer, awarded patents related to PCR, DNA Isolation and Sequencing, USA
Dr. Lidiya Angelova, MSc in Biology, PhD in Microbiology, Former researcher at the National Institute of Allergy and Infectious Diseases (NIAID), Maryland, USA
Dr. Fabio Franchi, Former Dirigente Medico (M.D) in an Infectious Disease Ward, specialized in “Infectious Diseases” and “Hygiene and Preventive Medicine”, Società Scientifica per il Principio di Precauzione (SSPP), Italy
Dr. med. Thomas Binder, Internist and Cardiologist (FMH), Switzerland
Dr. Stefano Scoglio, B.Sc. Ph.D., Microbiologist, Nutritionist, Italy
Dr. Paul McSheehy (BSc, PhD), Biochemist & Industry Pharmacologist, Loerrach, Germany
Dr. Marjolein Doesburg-van Kleffens, (MSc, PhD), specialist in Laboratory Medicine (clinical chemistry), Maasziekenhuis Pantein, Beugen, the Netherlands
Dr. Dorothea Gilbert (MSc, PhD), PhD Environmental Chemistry and Toxicology. DGI Consulting Services, Oslo, Norway
Dr. Rainer Klement, PhD. Department of Radiation Oncology, Leopoldina Hospital Schweinfurt, Germany
Dr. Ruth Schrüfer, PhD, human genetics/ immunology, Munich, Germany,
Dr. Berber W. Pieksma, General Practitioner, The Netherlands,
Dr. med. Jan Bonte (GJ), Consultant Neurologist, the Netherlands,
Dr. Bruno Dalle Carbonare (Molecular biologist), IP specialist, BDC Basel, Switzerland
Read the full open letter at cormandrostenreview.com
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About the author: John O’Sullivan John is CEO and co-founder (with Dr Tim Ball) of Principia Scientific International (PSI). John is a seasoned science writer and legal analyst who assisted Dr Ball in defeating world leading climate expert, Michael ‘hockey stick’ Mann in the ‘science trial of the century‘. O’Sullivan is credited as the visionary who formed the original ‘Slayers’ group of scientists in 2010 who then collaborated in creating the world’s first full-volume debunk of the greenhouse gas theory plus their new follow-up book.
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K Kaiser
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In other words:
The daily numbers of new COVID-19 “cases,” as reported for the U.S. by the Centers for Disease Control ( https://covid.cdc.gov/covid-data-tracker/#cases_casesper100klast7days ), for Germany by the Robert Koch Institute ( https://www.rki.de/EN/Content/infections/epidemiology/outbreaks/COVID-19/COVID19.html ), and for the world (covering 191 countries) by the Johns Hopkins University ( https://coronavirus.jhu.edu/map.html ) are basically meaningless.
With the next common flu (also caused by a type of corona virus) season coming about soon, the inability to differentiate between that cause from COVID-19 – and all the restrictions and conditions placed upon people far and wide for nearly all of 2020 — are the real catastrophe.
For example, even some Fundamental Rights (as guaranteed in The Canadian Charter of Rights and Freedoms), or as written in other “constitutions” have been suspended and/or curtailed for the reason of COVID-19 being (as claimed by the World Health Organisation) a pandemic.
If the signatories to this Open Letter are correct (which I think they are), the entire world appears to “have been taken in.”
The damage to the personal health and financial survival of millions of individuals, businesses and, actually, whole countries that have so been deceived will linger on for many years! – ALL FOR WHAT?
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René Civile
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First
We acknowledge and Salute all mentioned parties in this publication for their Splendid and Brave cooperation in act and condemnation of the RT-qPCR test. We Hail you all.
Our AX0 thinktank followed the course of the covid19 since the first days of 2020 from helicopter perspective of Risk and Crisis management to withnes clinical how action has been taken by different parties. The high numbers of deceased in China, wasn’t to surprising since many in wuhan referred themselves primarilly to physicians using the ancient oriental way of treating illnes. (Later it was discovered due to repeated and re-infection, the individual immunesystem sort off accelerated to ‘overdrive’ causing severe a typical chain events, many of them lethal)
Because of the density of liiving in Wuhan, re-infection easilly was realised with forthcoming consequences.
Bergamo Italy,
Bergamo is in the heart of the most industrial and poluted district of Italy where life expectency considerably is lower then elsewhere in Italy. Hence, the apparent ‘ease’ covid struck, on itself couldn’t be seen as any measure of compare. The ‘explosive’ massive press coverage, contributed gravely to the ‘mass panic’ globally as a result of ease newstraveling anno 2020, via the internet. Also all kinds of theories spread by numerous parties contributed to the very negative newscoverage.
Noord Brabant, Netherlands
Here also a neglected aspect has been a contributor the appearing ‘explosive’ appearence of the outbreak of covid. It was in the midst of the regional carnaval festivities where people by nature were ‘packed’ and ‘crowded’ celebrating. As prior mentioned, here to a matter of re-infection caused the human immunesystem into a sort of overdrive with far reaching individual consequences. Later an other aspect was dicovered also contributing to the complex chain of reaction, overweight and obese.
Overweight in this region of the Netherlands isn’t uncommon.
The reaction of the Dutch government
AX0 found last weak of Februari the first reports published of people seamingly to be reinfected, an issue that has become later of grave (negative) importance. This Dutch CDC called RIVM, the governmental entity later to fully taking the lead in advising PM Mark Rutte and take the lead in inforation and press releases. as well as Health minister Bruno Bruins, and high ranked civil servants were pointed to the publications,. Astonishing no one was interested in the matter, no one seemed interested in the course and route covid has taken.
By refusal even to open doors for additional channels and sources of information, Mr. Jaap van Dissel, president of rivm, pointed to act only on information and advice of the WHO. Where it slowly then and later, became quite obvious of the most negative Chinese influence on the WHO, contributing to the very mild and surpressed information and statistics to the outer world initially.
AX0 partners keeped on pressing to rivm, civil servants, addressing Health Minister Bruno Bruins to take notice of incresing channels of information to also add to the overall information and statistics.
March 16 2020 PM Mark Rutte of the Netherlands addressed the nation, stating that ‘experts told him that…’ covid19 would become part of everyones life. That same press statement Rutte revealed that ‘the experts told him’ that everyone was to be subjected to covid19, therefor a herd immunity strategy was advised’. … ?!?!?
The ‘one and only test’ from day one is the here pointed out RT-qPCR test. In the early days, HM Bruno Bruins succumb to severe being overloaded emotionally that he collapsed during a rpesentation in the Dutch second chamber. On doctors advice he stepped down, to be succeeded by Hugo the Jonge.
Here things became quite peculiar…
Because of the, then knowledge and experience, thhe Nethrelands would face a state of ‘intelligent lockdown’. On several occasion, via several channels, AX0 partners continued to inform that this strategy might show disastrous becuase of the lighthearted seaming infectious nature of covid19. With the increasing actualized information flow, a full lockdown of the country, like later New Zealand followed, would be much more constructive and save to very sensitive groups like elderly and weak of condition to protect.
The rivm contiued to stay firm, (ill) advizing the audience and public where it became obvious and evident that people would become infected. At the same time the health organizations, GGD’s, starting to set up test facilities, and communication models to make appointments, started to interview callers wo wanted to be tested. According to rivm and newly appt HM Hugo the Jonge entrance to test facilities would be quite easy. In Practice professionals of the GGD’s carried out medical assessments by telephone(!!??), which in direct violation to the essentials of medical ethincs in the Netherlands,
The inadequate provision of information to the public of rivm, the ill medical interviews and assessment by telephone by GGD professionals, the inadequate ammount of test facilities, and ‘political misrepresentation’, contributed to a shear explosive outbreak of covid19 in the Netherlands, attacking just the groups MP Mark Rutte and HM Hugo de Jonge stated to want to protect. From the early days of the outbreak, the misrepresentation of facts and statistics, by rivm, by MP Mark Rutte, by HM Hugo de Jonge, and the GGD’s starting the use of the RT-qPCR tests.
On May 26, John Hopkins university journal published their findings of having tested the RT-qPCR testkit. The publication can be found here. https://www.hopkinsmedicine.org/news/newsroom/news-releases/covid-19-story-tip-beware-of-false-negatives-in-diagnostic-testing-of-covid-19
Here it became evident how inadequate the testkit. Warwick universities also came to same conclusion.
In the Netherlands again AX0 partners addressed GGD’s, ricm, civil servants of the Health Department, all who waved the information, referring to one and other, denied the information, labeling these as ‘fake news’ and all continued testing using the RT-qPCR testkit.
From that moment on things are becoming incresingly odd and peculiar in the Netherlands. Since if the false negatives, in at leas 25% of the cases, are relaeased, it is eminent there might be real covid19 infected persons, with the serious capability to prolong infection with the virus as well as contributing the continuing intestation of the audience, regardless any íntelligent lockdown’.
In the inquiries AX0 think tank partners continued to pursuit, increasingly it became more and more clear that for the large majority the covid19 virus would have mild to virtally non physical consequences. The virus is more disastrous for elderly aged 75+, people with obese/overweight, people with underlying negative medical conditions as also people with diabetes. All these has shown to be at risk, prolonged and extended by Dutch governmental entities.
Biggest risk assessment imaginable
To our horror the Dutch authorities, in spite of latest findings and experience of the RT-qPCR testkit, as in the papers here mentioned and aimed, at the sever mallfunctioning of the kit, conveyed to several Dutch governmental professionals, sources and entities, mainly through the social media, we have found the conduct of the Dutch government as of May 26 2020, more than reprehensible.and deplorible.
Every strategy against the Dutch society, Dutch economy, Dutch enterprises, has lead to grave economic disastrous consequences where the true extend of damages is yet to be assessed. In light of condemnation and rejection of the in publication of these.
Beside the deplorable and deliberate misrepresentation of scientific means where Dutch MP Mark Rutte, HM Hugo the Jonge, presiding head of the Dutch rivm Jaap van Dissel, and all political members of the cabinet, 2nd and 1st chamber of the Royal Kingdom of the Netherlands, falsely presenting fake statistics, (ab)using the Dutch Main Stream media, television, ill character journalists, to harness and take an entire Dutch society and economy hostage by continuous vile presentation of ill fact upon ill foundation, the dangerous inadequate here mentioned RT-qPCR test.
The vile act committed by Hugo de Jonge by illwill and abuse of power and authority to have an entire Dutch society subdued to accept vaccination by (ill) force and misreparesentation as well as ignoring the Dutch constitution in portraying to commit deliberate discrimination of those freely being vaccinated and those refusing any vaccination because of the tremendous vile pressure by Mark Rutte and Hugo de Jonge not in the least all those political individuals and civil servants, not stepping forward to protect the Dutch citizens they have promised and/or sworn to serve.
We especially like to acknowledge and pay our Respect and Gratitude to Flavio Pascino of Black Box TV, Pierre Capell, Dr. Peter Borger and Drs. Mario Ortiz Buijsse for their undersandable and comprehensible explaining of the covid19 virus, and the RT-qPCR test.
We ow the entire audience our utmost Gratitude for effort and steps made to this moment an retraction of the RT-qPCR.
Yours truly
René Civile CEO Partner
AX0 bv
Netherlands
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Dev
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The only way to stop a steamroller is with large obstacles in its path.
Both front and rear!
To end persecution of the innocent.
Thanks john – great summary.
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