Changes in Bleeding Becoming More Prominent

Endometriosis is a disease in which tissue similar to the lining of the uterus grows outside the uterus.

It can cause severe pain in the pelvis and make it harder to get pregnant.

Endometriosis can start at a person’s first menstrual period and last until menopause.

Hormonal therapies used to treat endometriosis include:

  • Hormonal contraceptives. Birth control pills, shots, patches and vaginal rings
  • Danazol. A is a synthetic steroid derived from ethisterone, an androgen similar to testosterone.
  • Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists. These medicines block the menstrual cycle and lower estrogen levels. This causes endometriosis tissue to shrink.
  • Progestin therapy. Progestin therapies include a tiny device placed in the uterus that releases levonorgestrel (Mirena, Skyla, others), a contraceptive rod placed under the skin of the arm (Nexplanon), birth control shots (Depo-Provera) or a progestin-only birth control pill (Camila, Slynd).
  • Aromatase inhibitors. The aromatase inhibitors used for endometriosis include letrozole and anastrozole.

Martínez-Zamora et al, evaluated patients with and without endometriosis with the first and second injections of mRNA COVID-19 vaccines (Pfizer or Moderna).

As with many studies, the majority had changes in their menstrual cycle.

The interesting observation was that those NOT on hormonal therapy had more bleeding and other symptoms.

Thus treatment for endometriosis appeared to lessen the impact.

Martínez-Zamora MÁ, Feixas G, Gracia M, Rius M, Quintas L, de Guirior C, Carmona F. Evaluation of menstrual symptoms after Coronavirus disease 2019 vaccination in women with endometriosis. Womens Health (Lond). 2023 Jan-Dec;19:17455057231176751. doi: 10.1177/17455057231176751. PMID: 37282979; PMCID: PMC10251079.

Vaccinations of any type should not cause misery for women who suffering from endometriosis.

This paper is important since I plan to advise the occasional patient who may be forced into vaccination to expect a rough ride of they are not on hormonal therapy.

See more here substack.com

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Comments (1)

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    Anapat

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    “The artificial hormone diethylstilbestrol (DES) was widely administered between 1947 and 1976 to prevent miscarriages in future mothers. Around 1976, it became clear that the use of DES had a series of serious side effects that affected future generations. Their daughters were at risk of abnormalities in the endometrium, pregnancy complications and genital deformations.” Mattias Desmet, 2022

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