Brain Injuries After COVID Vaccination

Written by Colleen Huber on April 24, 2023. Posted in Current News

There are back door routes to the brain. COVID vaccine developers have traversed a path through those doors. And they knew they had entered the brain by November 2020, before the vaccine rollout

We have 86 billion neurons in the human brain, and each of those connects with 10,000 other neurons. No other structure in the known universe rivals the brain’s complexity.

The brain is also the most exclusive club, so to speak, in the body. The gatekeeper is the blood-brain barrier (BBB). That barrier, shown in the second illustration below, is mostly composed of tight junctions between endothelial cells that line, in a single layer, the capillaries (our smallest blood vessels) that nourish the brain. So the BBB is in effect the capillary walls and the tight junctions between its cells.

However, to some extent, there is a liquid component to the BBB, in that the pristine cerebrospinal fluid (CSF) that bathes the brain and spinal cord is kept pure by the BBB.

At the risk of oversimplifying, if the central nervous system, which includes the brain and spinal cord, is the royalty of the body, then the skull and vertebrae and BBB are the castle walls, and the CSF is the moat—but a clean moat—unlike the medieval ones. Intruding molecules and pathogens would have to traverse both solid and liquid barriers.

Capillaries are the smallest blood vessels, and they are everywhere in the body. They are the U-turn points where arteries and then smaller arterioles give way to capillaries, then venules, and then veins in blood’s perpetual round-trip from the heart to everywhere else and back again. Anywhere you can point to on your body has a dense and intricate network of capillaries under the skin.

Image: University of Montana

The bottleneck of the BBB is comprised of the tight junctions between capillary wall endothelial cells, prohibiting passage of most substances, as detailed below. Those ubiquitous capillaries run through the entire body, and in the brain they are 40 micrometers apart, which is a space in which two neurons can fit. [1] So every neuron in the brain is nourished by an adjacent capillary.

Image: Diana Molleda

The Bottleneck at the Blood-Brain Barrier

For a molecule floating in the blood to travel from the blood to a neuron, it has the tightest challenge at the tight junctions between capillary endothelial cells, to exit the bloodstream. Then, once inside the brain, in the space surrounding neurons, if a molecule or a microbe is to arrive into the brain, it must next cross the brain cell (neuronal) membrane to enter that cell, and finally the nuclear membrane of the neuron.

The BBB rejects 98 percent of even small molecules and more than 99 percent of large molecules. [2] Charged or polar molecules and ions cannot pass. The large ones cannot pass directly, simply for not making it past the tight filtration of the BBB.

Oils, and substances that are soluble in oils, such as caffeine and nicotine, have a better chance of crossing the blood brain-barrier than water-soluble compounds. Certain small molecules may enter unchaperoned, such as oxygen and glucose. Nutrients such as B vitamins enter by way of saturable transport systems. [3]

Ions and charged polar molecules cannot cross, because they get stuck at the hydrophobic lipid layer. This simply means that because oily and watery fluids do not mix well, the fatty cell membrane disallows passage of most water-soluble substances, and keeps them out of the brain’s cells, unless they are carried in by other means.

And they knew they had entered the brain by November 2020, before the December 2020 vaccine rollout to the public.

So let’s look at what gets into the brain and how that happens.

A typical pharmacology strategy to enter the brain is chaperoning, in which substances that do not typically cross the BBB are compounded together with substances that do cross, which may mimic endogenous molecules.

Lipid nanoparticles (LNPs) carry medications into cells but rarely cross the BBB alone. Monoclonal antibodies have shepherded LNPs across the BBB. [4] Enzymes interact with cell membranes and can be used. [5]

Also, if previously non-BBB-crossing LNPs are linked to neurotransmitter-derived synthetic lipids, then they can cross the BBB and carry medications or other chemicals with them, and then those LNPs can enter neurons. [6] The reason for this is that neurotransmitters are typically in the brain—and belong in the brain—and generally pass without gatekeeping.

In other words, when a Trojan horse molecule such as an LNP is dressed up with a neurotransmitter that would typically belong in the brain, it fools the blood-brain barrier into allowing passage inside the brain.

Then COVID Vaccine Injection Occurred

COVID vaccines were advertised to “stay in the arm” following intramuscular injection, although the physiology of circulation, as known for centuries, pre-empts any such localization of a liquid in the body. [7]

Pfizer contracted with Acuitas Therapeutics in November 2020 to test the Pfizer vaccine in Wistar rats. [8] Their pharmacokinetics report shows that the COVID vaccine LNPs, as well as the messenger RNA (mRNA) they carried, were found within minutes and hours in the brain, eyes, heart, liver, spleen, ovaries, and other organs of the rats, including amounts of mRNA harvested from each sacrificed animal. [9]

Pharmacokinetics studies how much and how fast substances arrive to destinations throughout the body, after intramuscular injection (or other route).

The entire Pfizer report on these findings was submitted by the FDA [U.S. Food and Drug Administration] under court order. [10]

Released by Public Health and Medical Professionals for Transparency. Acuitas Therapeutics. [11] Final Report: Test facility study No. 185350, Sponsor ref No. ALC-NC-0552. Nov 9, 2020. p. 25 https://phmpt.org/wp-content/uploads/2022/03/125742_S1_M4_4223_185350.pdf

This available report text is in Japanese, but the tables at the end are all in English, such as this one. [12]

Other animal studies have shown that when mRNA is packaged in lipid nanoparticles (LNPs), those packets cross the blood-brain barrier. [13] [14] [15] Not only has the mRNA been detected in the brain, but it is also highly inflammatory. [16]

The Pfizer and Moderna COVID vaccines use mRNA to instruct human cells to make spike proteins. Messenger RNA is an intermediary between genes and proteins, in a relationship that is analogous to a template and a finished functional product, where mRNA is the instruction manual. In the case of the mRNA vaccines, spike protein is the product.

The Pfizer and Moderna vaccines contain pegylated liposome-type LNPs, meaning that they are attached to polyethylene glycol as a chaperone molecule. LNPs are released into the circulation following the vaccine injection, and some of those LNPs approach the blood-brain barrier.

It was once thought that LNPs could not cross the BBB unless attached to antibodies, in which case they accumulate in the brain within 24 hours and stay trapped there. [17]

Brain tissue was analyzed at 1 h, 6 h or 24 h after intravenous injection of liposomes packaged with [3H] daunomycin. From J Huwyler, D Wu, et al. Brain drug delivery of small molecules… https://www.ncbi.nlm.nih.gov/pmc/articles/PMC19511/

And it is still a challenge for liposomes to cross the BBB. [18] But the mRNA from COVID vaccines have been detected there, as shown above.

Now mRNA Is Inside the Brain and Past the BBB, so It Has Access to Neurons

Now that we have LNPs with their mRNA payload delivered past the BBB and into the brain, what do they do once they arrive to the fluid surrounding neurons? The rest is an easy journey for LNPs. Neurons take up LNPs—and they do so very efficiently, at 100 percent uptake, by means of apolipoprotein E, and usually without immune reaction at that point.

Apolipoprotein E is abundant in the brain—it is produced by astrocytes. [19] [20] The mechanism of uptake is endocytosis, in which the membrane of the neuron engulfs or swallows the approaching LNP.

That has been observed since at least 2013. [21] In this way, the Trojan Horse content of the LNP is delivered, because it was contained in a benign-seeming—to the neuronal membrane—package.

A Different Doorway to the Brain

Now at the same time, there is a different process going on. After injection with the mRNA vaccine, LNPs are traveling throughout the whole body, in accordance with long-understood principles of circulation.

Cells throughout the body take up these LNPs in endosomes and then the LNPs release their contents (the mRNA payload) into the cytosol of cells, [22] where the mRNA will then instruct the cell’s genetic machinery to produce spike proteins.

Evidence has accumulated that mRNA-generated spike proteins are being produced in various bodily organs following COVID vaccine injection. So throughout the blood, and on toward the brain, there are now free-moving spike proteins on the external side of the blood-brain barrier—that is, in the capillary walls. And it turns out that even they get into the brain. Here’s how the unchaperoned freely moving spike proteins cross the BBB:

Some of those spike proteins are traveling in the circulation and inevitably arrive to the blood-brain barrier. [23] So unlike the LNPs that travel through the membranes of neurons, the spike approaches the blood-brain barrier just as it does in the rest of the body, by way of the ACE-2 receptors, which happen to be abundant at the brain-blood interface. [24] By this route, the S-1 of the spike protein easily crossed the BBB in mice.”[25]

However, the spike protein is toxic in many ways. Each subunit of the spike protein was found to cause a dysfunctional leaking of the BBB. Within 2 hours of spike protein exposure, barrier permeability was seen. [26] It was also found that the spike protein was taken up readily at the capillary endothelial cells of the BBB, which opened that barrier also to spike protein entry to the brain. [27]

So there is an unfortunate feedback loop of earlier-arriving spike proteins widening the gates for later-arriving spikes to enter the brain. The Rho-A molecule seems instrumental in this prying apart mechanism at the tight junctions. [28]

Yet another proposed route of access to the brain is described by Seneff et al., by means of migration of mRNA-containing LNPs via the vagus nerve toward and into the brain. [29]

Brain Injuries Observed by Pfizer

The following screenshot from Pfizer’s documentation to the FDA, released under court order, shows a small part, listed alphabetically, of observed injuries in Pfizer’s clinical trial. [30] Because central nervous system, cerebral, and cerebellar all begin with ce, we can see the injuries they found at the blood vessels of the brain and central nervous system in this one screenshot.

These were injuries found by Pfizer in their 44-thousand-person clinical trial in late 2020. Many of these injuries observed by Pfizer, and submitted to the FDA, in their clinical trial are life-threatening.

For example, cerebral venous sinus thrombosis, which is among those adverse events listed in the screenshot above, is an otherwise rare blood-clotting event that blocks an essential route for blood to exit the brain. As the pressure of blood builds up in the brain, swelling, hemorrhage, and consequent damage to neural structures occur.

You may note that these thrombosis injuries are technically outside the BBB because they occur in a blood vessel. However, any clot in a blood vessel anywhere in the brain has the effect of what is called a watershed infarct. This is what happens in a stroke, or in a smaller injury, a transient ischemic attack.

What this means is that the blood vessel that is blocked by a clot has smaller blood vessels emanating from it in a wedge or pie shape. Now, since the clot became stuck there, all of the tissues in that pie-wedge—the watershed—have been deprived of the oxygen and the nutrients that moving blood would normally bring through those now occluded vessels.

As a result, some tissue inside the blood brain-barrier becomes so damaged that any of the following—memory, cognition, speech, vision, other senses, mobility, and other voluntary muscle control and/or other abilities—can be and are injured—as I will show below.

However, injuries of brain tissue that is protected by the blood-brain barrier are also evident following COVID vaccination, even without detected thrombosis.

This is taken from a long document, read the rest here theepochtimes

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