Antiparasitic drug Ivermectin kills coronavirus in 48 hours
Around the world, scientists race to develop a vaccine or treatment against the coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Now, a team of researchers has found that a drug already available around the world can kill the coronavirus in a lab setting in just 48 hours.
The drug, Ivermectin, an antiparasitic medicine, is an inhibitor of the virus SARS-CoV-2 in-vitro and can effectively cause a reduction in virus at 48 hours in cell cultures. The FDA-approved drug can be used for repurposing to treat patients affected by COVID-19, which has spread to 184 countries and territories.
The researchers at Monash University in Melbourne, Australia, have published their study in the journal Antiviral Research, showing how this already widely-used drug may help combat the current global pandemic rippling across continents.
Reduced COVID-19 viral RNA
The team worked with the Peter Doherty Institute of Infection and Immunity. They showed that Ivermectin reduced COVID-19 viral RNA present in cell culture by as much as 93 percent after 24 hours and by 99.8 percent after 48 hours, at around a 5,000-fold reduction in coronavirus RNA, hinting that the medicine can potentially eradicate the virus.
“We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours, there was a significant reduction in it,” Dr. Kylie Wagstaff of the Monash Biomedicine Discovery Institute, said. “Ivermectin is very widely used and seen as a safe drug. We need to figure out now whether the dosage you can use it in humans will be effective – that’s the next step,” Dr. Wagstaff added.
The researchers, however, cautioned that the tests performed in the study were in vitro, and human trials are still needed to determine the efficacy and safety of the drug against the coronavirus. Ivermectin has also shown effectiveness in vitro against a wide range of other viruses, such as the influenza virus, Zika virus, and the human immunodeficiency virus (HIV).
Repurposing Ivermectin
Ivermectin is an approved drug to treat parasitic conditions, such as rosacea, head lice, and scabies. It was developed in 1975 and has been widely used across the globe since the early 1980s.
“In times when we’re having a global pandemic, and there isn’t an approved treatment, if we had a compound that was already available around the world, then that might help people sooner. Realistically, it’s going to be a while before a vaccine is broadly available,” Dr. Wagstaff explained.
Though the mechanism of action by which Ivermectin works on the coronavirus is still unknown, the drug works on other viruses by stopping them from inhibiting down the host cells’ ability to detect and fight them.
Ivermectin, therefore, warrants further investigation for possible benefits in humans. Further trials should be performed to make sure the drug is effective. If it is effective on humans with coronavirus, it can be widely used to treat affected populations since it already went through approval by the U.S. Food and Drug Administration (FDA).
Countries grapple against COVID-19
Many countries are unprepared for the coming of the coronavirus disease, which emerged in China in December 2019. Since then, it has spread to most countries across the globe, touching all continents except Antarctica.
Sources:
- Monash University. (2020). Possible coronavirus drug identified by Monash University scientists. https://www.monash.edu/discovery-institute/news-and-events/news/2020-articles/possible-coronavirus-drug-identified-by-monash-university-scientists
- Coronavirus COVID-19 Global Cases by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) – https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6
Journal reference:
- Caly, L., Druce, J., Catton, M., Jans, D., and Wagstaff, K. (2020). The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Research. https://www.sciencedirect.com/science/article/pii/S0166354220302011
See more here: news-medical.net
Header image: MedPageToday
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richard
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Betting there will be more testing than the covid vaccines.
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richard
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Abstract
Ivermectin proposes many potentials effects to treat a range of diseases, with its antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective against many microorganisms including some viruses. In this comprehensive systematic review, antiviral effects of ivermectin are summarized including in vitro and in vivo studies over the past 50 years. Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2. Furthermore, there are some studies showing antiviral effects of ivermectin against DNA viruses such as Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, and bovine herpesvirus 1. Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. In vivo studies of animal models revealed a broad range of antiviral effects of ivermectin, however, clinical trials are necessary to appraise the potential efficacy of ivermectin in clinical setting.https://www.nature.com/articles/s41429-020-0336-z
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Mervyn
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How long will it be before ‘Big Pharma’ comes down hard on Monash University, trashing its Ivermectin research that threatens the experimental jabs, which are not working and are causing too many injuries and deaths?
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Karma Singh
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Just how old is this article????
It does not read as though it had been written this year.
One of the unmentioned problems is, “As the “virus” has never been found and isolated, how, on Earth, can you determine that Ivermectin has killed it?”
Ivermectin has proven itself extremely useful in treating severe influenza (which is what “Covid-19” actually is). Empirical evidence is valid evidence because easily repeatable. You don’t need the genome of the phantastic “virus” to prove that it works – you just have to use it as directed.
Blessed be
Karma Singh
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