more evidence of medical malfeasance

Well of course! Now that we know that billions of people’s cells might be making aberrant proteins, for unknown periods of time, we can simply sweep these people under the rug, ‘fix’ the product, and keep on makin’ money

Let’s go slidin’ down the slippery sequence slope of gene therapy straight to the Gates of hell.

With this phrase to be engraved in the history of the massive Covid vaccination campaign, the esteemed Canadian researcher, biochemist, immunologist and molecular biologist Jessica Rose (Source 1), author of multiple fundamental discoveries on the contamination of mRNA genetic sera, best describes the disturbing importance of an article published by University of Cambridge in relation to an enlightening scientific research which confirmed to the global scientific community the dangerous experimental use in the Pfizer-Biontech and Moderna mRNA vaccines of what we do not hesitate to define as the “Diabolical Molecule” because it is a biological human component modified twice in the laboratory. 

(Source 1), author of multiple fundamental discoveries on the contamination of mRNA genetic sera, best describes the disturbing importance of an article published by University of Cambridge in relation to an enlightening scientific research which confirmed to the global scientific community the dangerous experimental use in the Pfizer-Biontech and Moderna mRNA vaccines of what we do not hesitate to define as the “Diabolical Molecule” because it is a biological human component modified twice in the laboratory.

This is the double alteration of Uridine transformed into Pseudourine with the first synthetic biochemical alteration and then into N1-methylpseudouridine initialed “m1Ψ” as an acronym for N1-methyl-Ψ in which the Greek letter “Psi” was used to name Psueudoridine .

Uridine is an organic compound, nucleoside, made up of the coupling of a molecule of ribose and one of uracil. Uracil is one of the two pyrimidine nitrogenous bases that form the nucleotides of RNA nucleic acid.

This manipulation was designed by the Hungarian biochemist Katalin Karikó, awarded the 2023 Nobel Prize for Medicine precisely for having laid the foundations of mRNA vaccines, in order to “deceive” human cells into recognizing the synthetic mRNA as harmless human RNA …

I apologize to the biochemistry experts for any transcription mistakes I may make trying to translate from a difficult chemical language the portentous scientific essence of the abundant technical quotations in the article published by Rose on her Substack, from which we will only extrapolate its introduction.

Martin: “Pseudouridine Killer in the Vaccines for Depopulation”

This analysis comes surprisingly providential as on Gospa News International we have just reported the summary of a conference by the famous patent expert David E. Martin in which he narrated in recent weeks the story of SARS-Cov-2 as a bacteriological weapon built in 58 years of military research on coronaviruses and that of mRNA vaccines, in his opinion, knowingly spread in a mass experiment for the search for vaccines against HIV-AIDS and cancer but also aimed at global depopulation.

In a very detailed article the American osteopath doctor Joseph Mercola wrote that «Martin points out that even if they don’t unleash any other bioweapons, the desired death toll may still be achieved, because they used pseudouridine in the mRNA shots, which is causing “turbo cancers”».

Because: «Pseudouridine suppresses cancer-controlling agents and promotes oncogenic activity in the body, and this has been known since 2018, so its inclusion was hardly an accident.

It’s a conspiracy, alright. But not a conspiracy theory in the dismissive sense.

It’s a global conspiracy by identifiable agents who have, for nearly 60 years, plotted to commit, and profit from, the greatest genocide the world has ever seen, while hiding behind the false veneer of “public health.”».

Well today, both the University of Cambridge and other authoritative scientists from around the world implicitly confirm that all those vaccinated with Covid mRNA with Moderna’s Spikevax and Pfizer-Biontech’s Comirnaty have been and continue to be unpaid and, above all, unaware human guinea pigs.

Precisely because of this altered nucleoside…

The Disturbing Article from Cambridge University

The comment by the researcher Rose that we reported in the incipit of the article referred to the text of the University of Cambridge (Source 2) in relation to the study “N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting” by Mulroney et al. published on December 6, 2023 by Nature after more than a month of review.

«Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses» is the eloquent title of the scientific text published by the British university.

«The latest developments, led by biochemist Professor Anne Willis and immunologist Dr James Thaventhiran from the MRC Toxicology Unit at the University of Cambridge, build upon previous advances to ensure the prevention of any safety issues linked with future mRNA-based therapeutics. Their report is published today in the journal Nature» we read in the unsigned article.

«The researchers identified that bases with a chemical modification called N1-methylpseudouridine – which are currently contained in mRNA therapies – are responsible for the ‘slips’ along the mRNA sequence» adds the university website.

In collaboration with researchers at the Universities of Kent, Oxford and Liverpool, the MRC Toxicology Unit team«tested for evidence of the production of ‘off-target’ proteins in people who received the mRNA Pfizer vaccine against COVID-19. They found an unintended immune response occurred in one third of the 21 patients in the study who were vaccinated – but with no ill-effects, in keeping with the extensive safety data available on these COVID-19 vaccines».

Despite disturbing the article already appears biased as it is aimed at “minimizing” the adverse reactions, even lethal one, that are accumulating in pharmacovigilance systems around the world, which have been confirmed by an alarming article in the journal Science, by the regulatory bodies from all over the world (EMA, FDA, etc.) and which led Moderna and Pfizer-Biontech to include the risk of lethal myocarditis in the information leaflets of their genetic drugs…

British Study: “Incorrect mRNA Translation may Increase Toxicity”

But it is the same authors of the study whose first signatory is Thomas E. Mulroney (Source 3), associate researcher of the Toxicology Unit of the MRC in Cambridge, who wrote the shocking considerations from a biochemical point of view in the conclusions.

«We show that 1-methylΨ is a modified ribonucleotide that significantly increases +1 ribosomal frameshifting during mRNA translation and that cellular immunity to +1 frameshifted products can occur following vaccination with mRNA containing 1-methylΨ.

To our knowledge, this is the first report that mRNA modification affects ribosomal frameshifting. Alongside this impact on host T cell immunity, the off-target effects of ribosomal frameshifting could include increased production of new B cell antigens».

And they further add:

«These findings are of particular importance to our fundamental understanding of how ribonucleotide modification affects mRNA translation, and for designing and optimizing future mRNA-based therapeutics to avoid mistranslation events that may decrease efficacy or increase toxicity».

We will not delve further into the technical references but return to the analysis published by Jessica Rose in her Substack, making an extreme summary of it and advising professionals to read the text full of important images.

Let’s start with the comment added under the research published by Nature by her together with David Wiseman, L. Maria Gutschi, David J. Speicher, Kevin McKernan.

Alongside the Canadian biologist they were already co-authors of the study “DNA fragments detected in the monovalent and bivalent Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada: exploratory dose-response relationship with serious adverse events” which induced the EMA to confess that Pfizer hid the use of the very dangerous SV40 gene in its vaccine, which can cause tumors.

The same research encouraged the bioimmunologist Robert Malone to denounce the presence of the antibiotic resistance gene in the Moderna one, pointing out also that the pharmaceutical company was aware of the tumor risks of mRNA biotechnology as reported in its own patent.

We have written extensively about these topics in three investigations, one of which – on antibiotic resistance gene – is a world exclusive.

Alarm of American Scientists for the New Research

Let us therefore see the content of the comment by Rose and colleagues (Source 1) on Cambridge’s research:

The paper provides evidence for the formation “off-target” or unintended proteins following vaccination with BNT162b2 due to frameshifting. Given the proposed mechanism, a similar problem is likely to exist for the Moderna product.

While the authors have not isolated samples of these proteins from vaccinated patients or animals, their existence is evidenced by the specific cellular immune responses elicited to frameshifted proteins the authors synthesized. It is not clear why B cell – antibody responses were not studied.

The authors state that “Although there is no evidence that frameshifted products in humans generated from BNT162b2 vaccination are associated with adverse outcomes.”

It is unclear how it is possible to make this statement, given:
• The small number of vaccinated subjects (n=21) providing samples.
• This was not a controlled trial.
None of these subjects had reported undue effects of vaccination. Accordingly, the sample is subject to selection bias.
• The toxicology of these unintended proteins must be studied.
• The authors acknowledge the misdirected immunity “has huge potential to be harmful.”

Translated into simpler words, no one has verified the selection methods of the samples which may have been chosen precisely because they did not have serious adverse reactions.

Furthermore, in the interests of expertise we read that the two Cambridge scientists Thomas E. Mulroney and Anne E. Willis «are inventors of a pending patent application (2305297.0) relating to mRNA technology» while in the information on the authors it is discovered that Alexander J Mentzer works at the Wellcome Center for Human Genetics, University of Oxford.

Wellcome, with the Bill & Melinda Gates Foundation and the World Economic Forum, is among the founders of the Ngo CEPI (Coalition for Epidemic Preparedness Innovations) which has already launched the SKYCovion vaccine together with the London-based GSK, managed by CEO Emma Walmsley who is also director of Microsoft, and SK Bioscience.

But let’s go back to the analysis made by Jessica Rose on the Cambridge researchers’ study: «The authors write that N1-methylpseudouridine affects the fidelity of mRNA translation via ribosome stalling that induces frameshifting. Frameshifting results in the production multiple, unique and potentially aberrant proteins». 

«The modified mRNAs for use in the COVID-19 products were codon-optimized for maximal protein expression in humans. Codon optimization, or synonymous codon replacement, rests on the idea that one can induce mutations throughout a gene of interest (like spike) based on an organism’s (like humans) codon usage bias, to increase translational efficiency and protein expression without altering the sequence of the protein.

But, it is well-known that codon-optimization can lead to protein conformation, folding and stability problems».

The Canadian immunologist further notes:

«Codon optimization could affect protein conformation, folding and stability, change post-translational modification sites and even affect protein function. Different rates of translation by different tRNAs, including those that exhibit wobble base-pairing (a tRNA that can recognize multiple synonymous codons) may actually be critical for determining the rate of translation.

The ribosome may slow and pause during elongation which may actually be necessary for proper protein folding. Therefore, codon optimization may disrupt the fine-tuned timing of translation and ultimately protein function».

 The Prophetic Seneff Study on Autoimmune and Neurocerebral Damage

He then refers to other studies that had reported the dangers of this biochemical manipulation (Source 1):

«Codon optimization can also lead to misfolding of mRNAs due to increased Guanine/Cytosine (GC content). Please read McKernan et al.’s preprint, Xia et al.’s paper and Seneff et al.’s paper to learn more about potential problems relating to codon optimization and GC content changes.

The latter group write: Synonymous codon replacement also results in a change in the multifunctional regulatory and structural roles of resulting proteins».

The risks to the human organism are clearly highlighted:

«There is, in fact, a significant enrichment of GC content (17% and 25% enrichments as per Pfizer and Moderna, respectively, as compared to SARS-CoV-2) as a result of the codon optimization that was done, and this can lead to “dysregulation of the G4-RNA-protein binding system and a wide range of potential disease-associated cellular pathologies including suppression of innate immunity, neurodegeneration, and malignant transformation”.

Increased GC content significantly alters mRNA secondary structure as well, and this can also lead to ribosomal pausing or stalling».

These considerations were expressed in a study published by illustrious scientists such as Stephanie Seneff, Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA, Greg Nigh, Immersion Health, Portland, OR, USA, Anthony M. Kyriakopoulos, Nasco AD Biotechnology Laboratory, Department of Research and Development, Piraeus, Greece and Peter A. McCullough, for Health Foundation, Tucson, AZ, USA, which was the subject of enormous censorship by specialized medical journals but we published in Gospa News thanks to an excellent summary by Dr. Mercola.

This is taken from a long document. Read the rest here vtforeignpolicy.com

Please Donate Below To Support Our Ongoing Work To Expose The Lies About Covid 19

PRINCIPIA SCIENTIFIC INTERNATIONAL, legally registered in the UK as a company incorporated for charitable purposes. Head Office: 27 Old Gloucester Street, London WC1N 3AX. 

Trackback from your site.

Comments (1)

  • Avatar

    Tom

    |

    Do these big pharma clowns know what mRNA substances really are? I bet they do but are never going to reveal those secrets. In a similar fashion, if you take 100 million people and examine their gut biomes, each would be somewhat different and no two exactly alike in makeup. Perhaps the same thing is happening with humans and mRNA poisons. This is why the fallout is all over the map. In documents from fizer, they listed well over 1,000 variable diseases that could result.

    Reply

Leave a comment

Save my name, email, and website in this browser for the next time I comment.
Share via