Electrical Device Zaps A COVID-19 Vaccine Into The Body
An electrical device that “gives DNA vaccines the boost they need to work in humans” receives $71M from the U.S. Dept of Defense.
A growing number of Americans – including military personnel – are opposed to vaccine mandates (see 1, 2, 3). Vaccine side effects, injuries, deaths have been reported for decades (see 1, 2, 3). They continue to be reported about the COVID jabs as well (see 1, 2, 3, 4). Nevertheless, pharmaceutical companies are continuing to invest in vaccines and also vaccine technology.
It took a global pandemic to accomplish one of the most significant advances in the history of vaccinology: widespread, commercial deployment of vaccines derived from nucleic acids. As of this writing, hundreds of millions of people have been vaccinated against SARS-CoV-2, the virus that causes COVID-19.
And most of those shots have been the Pfizer–BioNTech and Moderna offerings, which are both of a type known as an mRNA (messenger RNA) vaccine.
Conceived decades ago but released to the public for the first time during the pandemic, mRNA vaccines so far are living up to their promise. Both the Pfizer and Moderna vaccines have proven to be about 95 percent effective against the novel coronavirus.
In addition, this kind of vaccine can be tweaked with relative ease to target new variants of a virus, and its production does not rely on items that can be difficult to produce quickly in enormous quantities.
And yet, a couple of drawbacks of mRNA vaccines have also been widely noted over the past six months: They depend on deep-freeze supply chains and storage, and they can produce significant side effects such as fever, chills, and muscle aches.
So hopes remain high for another kind of nucleic-acid vaccine, one that makes use of DNA rather than mRNA. DNA-based vaccines have most of the advantages of mRNA vaccines, yet they produce no significant side effects—and, crucially, they don’t need to be refrigerated.
These attributes could make these vaccines a boon to rural and low-resource regions. “If we really have to vaccinate 7 billion people, we might just need every possible technology,” says Margaret Liu, chairman of the board of the International Society for Vaccines.
Inovio’s device uses a technique called electroporation to sneak a DNA vaccine into cells. Kate Broderick, Inovio’s senior vice president of R&D, has been working on this technique for years, but the pandemic provided both motivation and funding to accelerate development. Spencer Lowell
DNA vaccines come with a major challenge, however. When administered with an ordinary hypodermic needle, they’ve conferred only weak immunity, at best, in many human studies. But if a small, ambitious Pennsylvania company backed by the U.S. Department of Defense succeeds in its clinical trials, DNA vaccines—enabled by a new delivery technology—could soon join the fight against COVID-19, and a host of other viral illnesses.
The company, Inovio Pharmaceuticals, is using a technique known as electroporation, in which an electrical pulse applied to the skin briefly opens channels in cells to allow the vaccine to enter. After a standard vaccine injection, Inovio’s electroporation device, which looks like an electric toothbrush, is held against the skin.
At the press of a button, a weak electric field pulses into the arm, opening channels into the cells. The tool gives DNA vaccines the boost they need to work in humans—or so the company says. It’s an engineering solution to a biological problem.
With its overseas warfighters in mind, the U.S. Department of Defense (DOD) has backed Inovio’s approach with a US $71 million contract to scale up the manufacturing of its electroporation device, and an undisclosed sum to cover phase 2 and 3 studies of the company’s COVID-19 vaccine. And the Bill and Melinda Gates Foundation gave the company $5 million as part of an effort to increase equitable access to COVID-19 vaccines.
Inovio is now finishing phase 2 studies that are testing the vaccine’s safety and efficacy on relatively small groups in the United States and China, and those results are imminent. In the meantime, the company has ramped up manufacturing with a plan to supply hundreds of millions of COVID-19 vaccine doses to the global population, should the vaccine prove successful.
But here’s the rub: The electroporation tool is essential to Inovio’s vaccine, but it also adds a layer of complication. It’s both an enabler and a handicap. Inovio must manufacture not only the vaccine but also the device and its disposable tips. Any vaccination site planning to administer Inovio’s vaccine will need not only the device but also people who know how to use it.
The public will have to develop trust in a new apparatus. And all of this will have to happen during a pandemic and a frenzied vaccine rollout characterized by rampant misinformation and, in some quarters, an unwillingness to be vaccinated.
Given that backdrop, the idea of complicating mass vaccinations with an electric device has drawn skepticism. “This is not standard methodology for giving vaccines,” notes John Moore, an immunologist at Weill Cornell Medicine, in New York City. The technique might work, but “how practical it is is another question entirely,” he says.
Neither the skeptics nor tough questions from regulators have deterred Inovio. Nor has the fact that, despite more than a decade of research and development in other disease areas, the company has yet to bring a DNA vaccine to market. These are hardly normal times.
The coronavirus has propelled many other novel technologies, medicines, and vaccines into the mainstream, and in the process has created massive business success stories. Inovio is betting that its technology will make it into that elite group of pandemic-era winners.
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Bevan
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Stop this madness before humanity is wiped out. These are gene altering drugs. As every person has a unique set of DNA, no one can predict what effect a gene altering drug can have on an individual.
This is why there have been tens of thousands of deaths and millions of disabilities arising from the mRNA injections that are now being used on ignorant people while the rest go unharmed – so far ???
It all gets back to Hitler and his Dr Mengele aiming to produce a superior race. Doctors playing God with our DNA is potential suicide. Leave it to evolution to develop the human race to fit with the ever-changing environment. It has got us this far with remarkable results. Learn to appreciate and enjoy what we already have.
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Howdy
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This article is utterly ridiculous!
All the jabs so far are for nought because: “An electrical device that “gives DNA vaccines the boost they need to work in humans””
“vaccine rollout characterized by rampant misinformation”
This article is part of that,
“Neither the skeptics nor tough questions from regulators have deterred Inovio.” “the company has yet to bring a DNA vaccine to market.”
They’re getting well over 71 million just for phase 1. Why would they jack it in? It’s easy money. Jobs for the boys. No previous experience needed.
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itsme
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‘And yet, a couple of drawbacks of mRNA vaccines have also been widely noted over the past six months: They depend on deep-freeze supply chains and storage…’
so true, we don’t want that toxic graphene oxide to start activating that magnetic force before it’s in ‘dem arms’ do we?
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Tom
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What a bunch of horsecrap. the mRNA poison are not living up to anything except setting the stage for massive deaths in the coming months and years. 95% is the fake RRR calculation used only in the trials where everything is peachy-keen. When out in the real world, these poisons have an ARR, or absolute risk reduction of 1%…that is the real denominator that should be used.
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Twila Tharp
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This is a rubbish article. What’s going on? I won’t waste my time reading inaccurate and horrifying creative writing exercises written by sadistic wanna be’s.. THE VACCINE DOESN’T WORK. IT ISN’T A VACCINE. IT WAS FIRST DEEMED GENE THERAPY AND IT IS NOW BEING INVESTIGATED AS TO BEING A BIOWEAPON, The Coronavirus 19 virus has never been isolated. The PCR tests are not fit for purpose.
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FarthingtonMacMananus
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Listen, it’s a vaccine.
Like every other vaccine, it grants no immunity, has massive amounts of side effects, is designed for the purpose of industrial exploitation, based on fraud, to sell shit…assuming you have religious belief in the concept of phantom unproven horseshit like contagion, viruses, unnecessary vaccines…to sell more of that…coz that industry requires your belief and sickness.
The only difference is the methodology. All of the vaccines are for degeneration, abuse, offense. Their mechanistic functions change, the principles don’t. No vaccine ever has been a health boon.
If you do not believe in them and you are not sick, they are…????
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M
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I am one of the 400 from INOVIO INO-4800 Phase 2 1 MG Double Arm Trial. It has been 10 months since my first of 2 injections. I have experienced zero Adverse Events from the shot or electroporlation. In fact everyone in my household has had covid except me. A couple of tech responses. The needle is less than a 1/4 inch in length. The Plasmid is injected and the cell walls are thinned after the electric pulse. Thats how it gets into the cell. The Cell picks up the plasmid reads what it says and begins to produce the mRNA “naturally”. Thats why no one gets sick, and no one dies. Your own cell is making the mRNA and becuase it does that it also makes memory T cells for the next time it encounters the spike protein of Covid-19. Thats why 10 months into this I dont need a booster. My cells recall the recipe unlike synthetic mRNA it did not make. Inovio is real and what they are doing is changing the world. I was happy to be part of the trial.
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FarthingtonMacMananus
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Yeah nice try.
Now, everyone, take a good look at robot industrial pharmaceutical marketing.
Or, listen to this:
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FarthingtonMacMananus
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There’s absolutely every part of your shit that you spewed there that I can destroy.
As a random clue, T-cells respond to toxicity. The body reacts to toxic inputs with “immune response”. “Immune response” is in and of itself, a sign of adverse reactions to unnecessary toxicity.
I’m GOING TO SEND YOU TO HELL!
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FarthingtonMacMananus
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Endless T-Cell sort of responses for the vaccine sort of proponents. Promises from the deepest parts of my unbeing.
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FarthingtonMacMananus
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Hey fuckface.
Tell me about how it is a natural compound like PQQ, which has about 20000x redox cycle capacitance is associated with “immune system memory”, whereas vitamin C, is not?
Can you grok that?
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FarthingtonMacMananus
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Aside from that redox cycle “immune system memory” capacitance (oh shit, I just gave you a clue…i should never do that), PQQ is also associated with crucial development. Almost like…if you have redox balance…growth is a thing. And when you induce say, ANY vaccine, by virtue of oxidative, nitrosative and other toxic responses, it can NEVER be useful or beneficial.
Though I guess, you should go get some super hardcore estrogen injections in your bicep for preparation of when I’m going to fuck you.
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FarthingtonMacMananus
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I’m going to tell you again. Last time.
If you try to homogenize treatment of bodily status (like say, vaccines, or protocols)….you failed. Absolutely no use for you. You are too stupid to be allowed to exist. Promise.
Secondly, if you inject infants, for instance, based on your fraudulent bullshit I am going to revel in you being murdered.
Thirdly. Hahahhaahahaha.
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FarthingtonMacMananus
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Oh sorry, Almost forgot to leave my signature.
47, but twice.
http://www.astrodreamadvisor.com/M_white_elec_wizard.html
Also…
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FarthingtonMacMananus
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wew wew
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FarthingtonMacMananus
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Am I cruel enough for you? Not fucking cool enough for you? Wew wew…I tear your soul in two.
It’s like you don’t believe me? But you believe in covid. Hilarious.
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FarthingtonMacMananus
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Hey, this is kinda off topic. But basically, there’s HUGE bias on the sun now which means….gl with that.
FarthingtonMacMananus
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No jokes, a minute ago, this gap on this graph didn’t exist:
https://www.lmsal.com/solarsoft/latest_events/
Holy SHIT are some of you northern hemisphere motherfuckers going to suffer soon.
FarthingtonMacMananus
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Amazing, that gap got fixed real quick there.
But, unfortunately, I have unfriendliness for them over the next few weeks. And then they get to the harsh parts.
FarthingtonMacMananus
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Let me remind you, millions of infants, children. Every day, injected with toxic industrial horseshit based on fraud that can only degenerate them.
You support that? I kill you.
FarthingtonMacMananus
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See I’m incapable of forgetting. My memory is frightening. That makes the possibility of forgiveness, in most cases, a non-sequitur.
FarthingtonMacMananus
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You can’t be going around stabbing children with toxic shit, based on your ignorant egotistical institutional position, which is homogenized bullshit and saying shit like “forgive me please” while you still have a job.
FarthingtonMacMananus
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So, you either quite your job and find forgiveness. Or you go to hell.
Simple stuff.
FarthingtonMacMananus
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So, you either quit your job and find forgiveness, legitimately. You know, reflection, consideration, research, caution. The sort of things you’re unfamiliar with. Or you go to hell.
Simple stuff.
FarthingtonMacMananus
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Sorry about that, but it’s okay, I’ll stop posting for the next, what, 3, 4 weeks, while I watch the bodycount.
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FarthingtonMacMananus
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Hey look, the gap is back:
https://www.lmsal.com/solarsoft/latest_events/
And magically, when the gap disappears (that’s a weird thing, right? something that’s not there disappearing)…there will be a special surprise for your “earth weather” for the next week or so.
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