4th Vaccine Dose Shows Negative Efficacy

Written by Megan Redshaw on January 2, 2024. Posted in Current News

An Austrian study showed more COVID-19 deaths among individuals who received four vaccine doses than among those who received fewer doses or no vaccinations.

A fourth dose of the COVID-19 vaccine may not be as effective as expected, according to a recent peer-reviewed study.

Researchers calculated COVID-19 deaths and SARS-CoV-2 infections from Nov. 1 to Dec. 31, 2022, in 3,986,312 individuals, comparing the outcomes of 281,291 who received four vaccine doses with 1,545,242 individuals who received three vaccine doses to determine relative efficacy.

During the initial study period, researchers recorded 69 COVID-19 deaths, 89,056 SARS-CoV-2 infections, and an overall case fatality rate of 0.08 percent. Relative vaccine efficacy for four doses was negative 24 percent compared with those who received three vaccine doses.

Additionally, researchers found more COVID-19 deaths among individuals who received four vaccine doses than among those who received fewer vaccine doses or no vaccinations.

“Negative efficacy basically means [there were] more deaths (or illnesses) in the vaccinated group compared to the unvaccinated group. Efficacy is a ”delta“ of unvaccinated deaths minus vaccinated deaths. Once vaccinated deaths exceed unvaccinated deaths, the delta becomes negative, and that yields a negative efficacy,” Brian Hooker, chief scientific officer at Children’s Health Defense, who holds a doctorate in biochemical engineering, told The Epoch Times in an email.

There was a 17 percent reduced risk among those who received four vaccine doses. However, the initial decreased risk of infection “rapidly diminished” and reversed itself in a six-month extended follow-up, leaving individuals who received four doses with a higher risk of infection than less vaccinated individuals.

Those with repeated previous and recent infections experienced significantly reduced reinfections, regardless of the vaccine dose.

More than 80 percent of vaccinated Austrians had received Pfizer’s COVID-19 vaccine during the initial study period, and 97.4 percent of individuals who had received four vaccine doses in the extended observation had received Pfizer’s vaccine.

During this extended study period, researchers recorded 225 COVID-19 deaths and 174,174 SARS-CoV-2 infections.

No significant differences for COVID-19 mortality were found in other groups, but fewer infections existed in the less vaccinated groups.

Any benefit they did receive initially rapidly waned—a finding similar to a March 2023 study. In this study, the relative vaccine efficacy of a third vaccine dose was 61.4 percent in the first month of follow-up and gradually declined to a relative vaccine efficacy of negative 45.7 percent.

Vaccine effectiveness against SARS-CoV-2 infection was negligible the first two weeks after the first Pfizer dose, increased to 36.8 percent in the third week after the first dose, and peaked at 77.5 percent in the first month after the second dose.

Researchers found that effectiveness builds quickly after a first dose, peaks during the first month after a second dose, and declines gradually in subsequent months.

By the end of the study, breakthrough infections reached 36.4 percent, with 77.2 percent of infections attributed to Pfizer’s COVID-19 vaccine.

Compared to individuals with three vaccinations, the age and gender-adjusted hazard ratio for all-cause mortality in those with four, one to two, and no vaccinations was 0.79, 1.17,  and 0.93, respectively.

Researchers noted the reduced infection risk did not translate to preventing COVID-19 deaths, according to their data.

They observed a 21 percent lower all-cause mortality risk in those receiving four vaccine doses than those receiving only three doses. However, when nursing home residents—who are at a higher risk of death due to age and comorbidities—were excluded, the number jumped to 37 percent, suggesting “healthy vaccinee bias.”

Healthy vaccinee bias assumes that individuals who are healthier and have lower risks of certain diseases are more likely to get vaccinated, while those in poorer health are less likely to be vaccinated.

“Healthy vaccinee bias may cause overestimation of rVE [relative vaccine efficacy], but this would not materially alter our findings, as we have not observed a protective effect for COVID-19 deaths anyhow,” the researchers wrote.

The authors of this study say it raises questions about whether recommendations for repeated vaccine boosters against COVID-19 are currently justified for the larger general population with a history of previous infections.

See more here theepochtimes

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