More researchers showing COVID-19 may not be infectious at all

A growing body of research suggests that a significant number of confirmed COVID-19 infections in the U.S. — perhaps as many as 9 out of every 10 — may not be infectious at all, with much of the country’s testing equipment possibly picking up mere fragments of the disease rather than full-blown infections.

Elevated ‘cycle thresholds’ may be detecting virus long after it is past the point of infection.

Confirmed cases of the disease have been the focal point of public health authorities and governments worldwide for many months, with countries across the globe working frantically to shore up their testing infrastructure and ensure that most citizens who want a COVID-19 test can obtain one with relative ease.

Many politicians, meanwhile — including most state governors in the U.S. — have tied reopening policies to the number of cases detected in the local community, with regions and localities often being permitted to reopen in staggered “phases” only when they have reached successively lower benchmarks of average new daily cases in the area.

Numerous institutions, meanwhile, have adopted testing protocols in an attempt to preempt the spread of the virus. American colleges and universities, for instance, have turned to mass testing in order to closely monitor incidences of the disease among students, particularly residential students living on campus.

Yet a burgeoning line of scientific inquiry suggests that many confirmed infections of COVID-19 may actually be just residual traces of the virus itself, a contention that — if true — may suggest both that current high levels of positive viruses are clinically insignificant and that the mitigation measures used to suppress them may be excessive.

‘Cycle threshold’ set very high for many tests

At issue is the method by which many COVID-19 tests detect a patient’s viral load within a given sample. Polymerase chain reaction tests, which have been widely deployed to determine if individuals are infected with the disease, function by amplifying DNA samples to the point that an antigen can be detected and classified.

The “cycle threshold” is the number of amplification cycles a PCR test goes through before a target pathogen is detected. A lower cycle threshold means that a higher amount of the virus was present in the sample; a higher threshold means the machine had to work harder to detect the virus in the sample, indicating a lower viral load and more likely a non-infectious patient.

According to a rundown of PCR tests compiled by the Foundation for Innovative New Diagnostics, many manufacturers of PCR tests set the cycle threshold cutoff for a positive sample at up to around 40 cycles, a level numerous public health officials believe is guaranteed to return what are effectively false positive results that have detected fragments of the virus.

“I’m shocked that people would think that 40 could represent a positive,” Juliet Morrison, a virology professor at the University of California, Riverside, told the New York Times in August.

Health authorities elsewhere have indicated similar skepticism of high-threshold tests. A spokeswoman for Taiwan’s Central Epidemic Command Center said in June that the agency only assigns positive cases to samples with Cts of 35 or less, with authorities there believing that any samples with Cts of more than 32 are likely (though not definitely) non-infectious.

A team of researchers at Oxford, meanwhile, wrote in a preprint paper last week that, based on a review of various sample collections, swabs requiring more than 30 cycles were “associated with non-infectious samples.”

Binary positive-negative test results — in which cycle thresholds are not considered — will “result in false positives with segregation of large numbers of people who are no longer infectious and hence not a threat to public health,” they wrote.

Preprint papers have not yet been through the peer review process, so their results and conclusions can be changed prior to full publication. Yet several other research projects have indicated similar results. One, published in April by public health authorities out of France, found that “patients with Ct values equal or above 34 do not excrete infectious viral particles.”

Similarly, a study out of Ireland seeking to determine “the duration of infectivity” of COVID-19 patients found that, of numerous samples subject to PCR testing, scientists were unable to achieve positive culture growth in any that required more than 34.3 cycles.

Both of those thresholds are notably smaller than the maximum number of cycles instituted by many test manufacturers, suggesting that there may be many nominally positive COVID-19 cases that are innocuous far as infectiousness and illness are concerned.

Echoing those concerns, researchers at Harvard in May argued that “the Ct value from positive test results, when interpreted in context, can help to refine clinical decision making,” and that a cycle threshold of around 34 may be a useful tool for determining when a patient is truly infectious and when he or she is merely carrying remnants of the virus.

Such a policy, if implemented, could have momentous implications for public health policy in the U.S. and elsewhere. Presently, in many industries and at many institutions, a single positive COVID-19 case can result in a complete shutdown of the affected company or university or elementary school, followed by a rush to have everyone tested out of concern that the virus may have spread.

A greater emphasis on the cycle threshold of positive tests may preempt such disruptive policies by signaling which positive test results are truly infectious and which are detecting low viral loads at much less threat of infectivity.

Early indications suggest the number of clinically trivial positive cases in the U.S. might be startlingly highThe New York Times said last month that a review of the cycle thresholds of positive cases in Nevada, New York and Massachusetts indicated that “up to 90 percent of people testing positive carried barely any virus.”

Those numbers, if extrapolated nationwide, could suggest that a significant proportion of the mitigation and preparation measures currently in place across the U.S. might be excessive relative to the actual level of infectious cases around the country.

Ultimately it can be difficult to determine the cycle thresholds used at laboratories across the country, making that kind of extrapolation difficult. A spokeswoman for LabCorp — one of the largest clinical laboratory groups in the world — said the company “does not include the CT value in result reporting.”

“Our CT cutoff is based on extensive validation,” she said, “and is within the accepted range to accurately identify individuals currently infected with SARS-CoV-2.” The company on its website says it has performed 13.5 million COVID-19 tests, about 15% of the country’s total number of tests.

At the Center for Evidence-Based Medicine at Oxford University, researchers stressed last month that “PCR detection of viruses is helpful so long as its limitations are understood; while it detects RNA in minute quantities, caution needs to be applied to the results as it often does not detect infectious virus.”

“If this is not understood, PCR results may lead to restrictions for large groups of people who do not present an infection risk,” they wrote.

Read more at justthenews.com


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Comments (5)

  • Avatar

    Bob

    |

    This is yet another example of the BIG LIE
    Remember when the official story was that radical Arab Muslims hijacked airliners (etc . . . ) this entire fiasco is a control freak production.
    The masks are only symbolic.

    Reply

  • Avatar

    Terri Jackson

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    The government website http://www.GOV.UK of 19 March makes it very clear Covid-19 is not infectious. Quick way to dig out this information is to Google it for 19th March

    Reply

  • Avatar

    Roger Higgs

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    Why aren’t tens of thousands of honest medical doctors across the world speaking out against the covid fraud? Scared for their jobs? Have they no conscience? It’s pathetic.

    Reply

  • Avatar

    Dean Michael Jackson

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    Really? Not infectious at all? imagine that, a non-virion being non-infectious!* Who would have thought?

    All me to clarify: The PCR non-test can’t identify a virus, it merely amplifies, then looks for SIMILARITIES between the retrieved RNA from the back of the throat (that’s elongated to around a 25 nucleotide long sequence) and a databank of RNA nucleotide sequences. This comparison process is called a Query Sequence; like running a fingerprint check without the amplification.

    The key word, as stressed, is similarity, and in the world of everything, especially DNA that has only four molecules that binds the double helix to its two phosphate/sugar backbones; (A), cytosine (C), guanine (G), or thymine (T).), similarities mean nothing because they’re everywhere along nucleotide sequences.

    Let’s simplify: Imagine criminal forensic science requiring only similarities for fingerprint identification! Yeah, just as with the false positive laden PCR test, 100% of the nation would be guilty of a crime every time a fingerprint check was run! Or how about forensic DNA matching requiring only similarities! Imagine running a forensic ballistic test and only looking for similarities in bullet striations! Now one can fully appreciate the fraud behind the PCR non-test.

    Got the picture?

    At my blog, read the articles…

    ‘House of Cards: The Collapse of the ‘Collapse’ of the USSR’

    ‘Playing Hide And Seek In Yugoslavia’

    Then read the article, ‘The Marxist Co-Option Of History And The Use Of The Scissors Strategy To Manipulate History Towards The Goal Of Marxist Liberation’

    Solution

    The West will form new political parties where candidates are vetted for Marxist ideology/blackmail, the use of the polygraph to be an important tool for such vetting. Then the West can finally liberate the globe of vanguard Communism.

    My blog…

    https://djdnotice.blogspot.com/2018/09/d-notice-articles-article-55-7418.html

    One can’t have an infection when a disease doesn’t exist:

    “We have also contacted Dr Charles Calisher, who is a seasoned virologist. In 2001, Science published an “impassioned plea…to the younger generation” from several veteran virologists, among them Calisher, saying that:

    [modern virus detection methods like] sleek polymerase chain reaction […] tell little or nothing about how a virus multiplies, which animals carry it, [or] how it makes people sick. [It is] like trying to say whether somebody has bad breath by looking at his fingerprint.”[3]

    And that’s why we asked Dr Calisher whether he knows one single paper in which SARS-CoV-2 has been isolated and finally really purified. His answer:

    I know of no such a publication. I have kept an eye out for one.

    This actually means that one cannot conclude that the RNA gene sequences, which the scientists took from the tissue samples prepared in the mentioned in vitro trials and for which the PCR tests are finally being “calibrated,” belong to a specific virus — in this case SARS-CoV-2.”

    https://off-guardian.org/2020/06/27/covid19-pcr-tests-are-scientifically-meaningless/?fbclid=IwAR3G6Fuq8C-8XW7szL43scbKOYFx78irq52A6ZQCRdZmPMWiHTqD_2jv4Zo#4

    Reply

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